宫颈毛玻璃样细胞癌4例临床病理分析

Glassy cell carcinoma of uterine cervix:a clinical and pathological study

目的探讨宫颈毛玻璃样细胞癌(GCC)的临床病理学特点、病理诊断和鉴别诊断及预后。方法对肿瘤标本做常规石蜡切片,行HE染色和免疫组化染色,光镜观察。结果 4例宫颈GCC患者的发病年龄分别为26、26、27和31岁。镜下见肿瘤分化程度较差,瘤细胞异型性及多形性十分明星,核分裂象多见,瘤细胞胞质内可见弥漫多量均匀分布的细颗粒,呈毛玻璃样;肿瘤间质内可见密集多量淋巴细胞、浆细胞及嗜酸性粒细胞浸润。免疫组化染色:瘤细胞p16(3/4)、AE1(3/3)、AE3(3/3)、CK5(2/2)和CK8(2/2)(+)。结论宫颈GCC多见于年轻女性,临床表现以阴道不规则出血为主,肿瘤呈菜花样。组织学上,肿瘤分化程度较低,癌细胞异型性明显,胞质呈玻璃样需与鳞状细胞癌、腺鳞癌鉴别。

Objective To explore the clinicopathological features, pathological diagnosis, differential diagnosis, and prognosis of glassy cell carcinoma （GCC） of uterine cervix. Methods The tumors were studied by using paraffin sections, H-E staining, immunohistochemical method （EnVision method） and observed under microscope. Results The 4 patient＇s ages were 26, 26, 27 and 31 years, respectively. Microscopically, the tumors were poorly differentiated. The tumor ceils presented with remarkable anaplastic and pleomorphic appearances and high mitostic activity. The cytoplasm of the tumor cells was glassy like because of so large number of fine particles being evenly distributed in it. In the stroma, there ware densely infiltrated lymphocytes, plasmacytes and eosinophilic granulocytes. Immunohistochemical stain revealed that the tumor cells presentedP16 ＋ （3/4）, AE1 ＋ （3/3）, AE3 ＋ （3/3）, CK5 ＋ （2/2） and CK8 ＋ （2/2）.