非酒精性脂肪肝患者检测血清胸腺素β4水平的意义

The Significance of Serum Thymosin β4 Levels in Patients with Non-alcoholic Fatty Liver Disease

目的检测非酒精性脂肪肝(NAFLD)患者血清胸腺素β4(Tβ4)的水平,并探讨其与患者生化指标的相关性。方法检测40例NAFLD患者血清Tβ4及生化指标,并与健康对照组40例比较。同时检测其中26例NAFLD患者接受水飞蓟宾或多烯磷脂酰胆碱治疗前后血清生化指标和Tβ4的水平。分别做受试者血清ALT、Tβ4水平特征曲线(ROC),比较两者对NAFLD的诊断,并对诊断界点(cut-off值)进行确定。结果NAFLD患者血清Tβ4水平明显低于对照组(P<0.01)。NAFLD组患者血清Tβ4水平与其血清ALT含量呈负相关(r=-0.330,P<0.05)。26例NAFLD患者治疗后血清Tβ4的水平高于治疗前的水平(P<0.01)。NAFLD组患者与对照组、NAFLD组患者治疗前后血清中TG、ALT、ASTm、GGT、TBIL、ALP、ALB、FPG的比较,差异均有统计学意义(P<0.05或P<0.01)。血清Tβ4与ALT比较的ROC曲线显示,血清Tβ4的曲线下面积(AUC)为0.906,cut-off值为4.8305mg/L,其灵敏度为85%、特异度80%均高于血清ALT。结论NAFLD患者血清Tβ4的水平明显降低,治疗好转后升高。血清Tβ4的水平比ALT能更灵敏地反映NAFLD患者的肝脏功能。,

Objective To investigate serum thymosin β4 （Tβ4） levels in patients with non-alcoholic fatty liver dis- ease （NAFLD）, and to explore the correlation between Tβ4 and serum biochemical parameters. Methods The serum Tβ4 lev- el and biochemical parameters were detected in 40 putients with NAFLD. In addition, the levels of serum Tβ4 and biochemi- cal parameters were detected before and after treatment with silibinin or polyene phosphatidyleholine in 26 NAFLD patients. The receiver operator characteristic （ROC） analyses for ALT and Tβ4 level were performed and cut-off value was determined. Results Compared with the healthy control group, serum Tβ4 levels were significantly lower in patients with NAFLD （P 〈 0.01）. There was a negative correlation between serum Tβ4 and ALT in patients with NAFLD （r=-0.330, P 〈 0.05）. The serum level of Tβ4 was significantly increased after treatment in 26 NAFLD patients （P 〈 0.01）. There were significant differences in levels of TG, ALT, ASTm, GGT, TBIL, ALP, ALB and FPG between NAFLD group and healthy control group （P 〈 0.05 or P 〈 0.01）. After treatment, the levels of TG, ALT, ASTm, GGT, TBIL, ALP, ALB and FPG improved in patients with NAFLD （P 〈 0.05 or P 〈 0.01）. AUC of serum Tβ4 was 0.906 with 4.830 5 mg/L cut off value. Its sensitivity was 85% and specificity was 80%, which were higher than those of ALT. Conclusion The serum levels of Tβ4 were significantly lower in NAFLD patients than those of healthy control. And the level of serum Tβ4 was significantly increased after treatment in NAFLD patients. The serum level of Tβ4 was a more sensitive index than ALT for patients with NAFLD.