曲美它嗪对大鼠心肌缺血挛缩的保护作用

Effect of trimetazidine on ischemic myocardial contracture

目的 探讨曲美它嗪 (TMZ)对心肌缺血挛缩的保护作用。方法 大鼠分为A、B、C、D4组 ,A为对照组 ,微流量灌注 (0～ 1ml/min)制成心肌缺血模型 ,实验前口服曲美它嗪 (3mg/d× 7d) ,灌流液中加入 1× 10 -6mol/L的TMZ ,观察缺血后心脏发展压力的变化。结果 口服曲美它嗪、灌流液中添加曲美它嗪组与对照组相比 ,心肌缺血后发展压力有明显改善。缺血 30min时 ,A组 :(4 .49± 0 .6 0 )kPa(1kPa =0 .75mmHg) ;D组 :(1.39± 0 .75 )kPa ,差异有非常显著性 (P <0 .0 1)。再灌注 15min时 ,A组 :(4 .2 8± 0 .77)kPa ;D组 :(1.36± 0 .2 7)kPa ,差异有非常显著性 (P <0 .0 1)。缺血后发展压力恢复率在复灌后 5min内明显改善 ,A组 :(74.3± 8.4) % ,D组 :(98.6± 3.2 ) % ,差异有非常显著性 (P <0 .0 1)。结论 曲美它嗪对心肌缺血挛缩有明显的保护作用。

Objective To study the protective effect of trimetazidine (TMZ) on ischemic myocardial contracture.Methods The model of ischemic contracture was made by using microvo lume technique.TMZ (3 mg/day) was administered orally for 7 days before experiment, and 1×10 -6 mol/L TMZ added to the perfusate. The postischemic change of cardiac developed pressure (DP) was observed.Results Pretreatment with TMZ and adding TMZ to perfusate significantly improved the postischmic cardiac DP [At 30 min of ischemia,group A:(4.49±0.60) kPa(1 kPa=0.75 mm Hg);D:(1.39±0.75) kPa (P< 0.01 );and recovery rate of DP,group A:(74.3±8.4)%;D:(98.6±3.2)%(P<0.01)].Conclusion Antiischemic agent TMZ can markedly ameliorate the ischemic myocardial contracture.