山东地区2003—2011年HIV抗体检测的临床现状及分析

Clinical situation and analysis on the detection result of HIV antibody in Shandong province from 2003 to 2011 SUN

目的探讨山东地区艾滋病（AIDS）感染现状，为临床AIDS监控及避免院内交叉感染提供依据。方法2003年1月至2011年12月，采用阿克苏第四代酶免检测试剂及免疫发光第四代检测试剂为399303例门诊及住院患者行HIV抗体初筛，采用北京万泰酶免检测试剂及硒标快速检测试剂行复检，阳性反应标本报送当地疾控中心采用免疫印迹方法进行确认。结果129例（129／399303=0．3230‰）患者确认为HIV-1抗体阳性，其中门诊患者54例（0．1352‰），住院患者75例（0．1878‰）。2003--2011年门诊患者HIV感染检出率分别为0．050‰、0．030‰、0．111‰、0．120‰、0．124‰、0．113‰、0．148‰、0．201‰、0．2152‰；住院患者HIV感染检出率分别为0．150‰、0．089‰、0．138‰、0．144‰、0．104‰、0．132‰、0．197‰、0．329‰、0．313‰；住院患者中内科患者61例、外科患者14例，以青壮年、农民居多。结论HIV感染率呈逐年增高趋势，住院所检出HIV-1阳性患者的特点．名为艾滋病期的患者．律寺人院常规榆测很有必要。

Objective To provide the basis for clinical acquired immunodeficiency syndrome （AIDS） surveillance and to avoid cross infection in hospital, we study the infection status of AIDS in Shandong province. Methods The fourth-generated Akzo＇s ELISA kit and the fourth generated Immunoluminometric detection reagent were used for HIV antibody screening for 399 303 cases of both inpatients and outpatients from Jan. 2003 to Dec. 2011. Beijing WanTai ELISA kit and Se-marked rapid detection reagent were used for re-detection, and the positive samples were sent to the local CDC for confirming test by Western Blot. Results The HIV-1 antibody detection results of 129 （0. 3230%0） patients were confirmed to be positive, including 54 （0. 1352‰） cases of outpatients and 75 （0. 1878‰） cases of inpatients. HIV infection rates in outpatients from 2003 to 2011 were 0.050‰, 0.030%0, 0. 111‰, 0. 120‰, 0. 124‰, 0.113‰, 0. 148‰, 0.201‰, 0.2152‰; and that in inpatients were 0. 150‰, 0.089%0, 0. 138‰, 0. 144‰, 0. 104‰, 0. 132‰, 0. 197‰, 0. 329‰, 0. 313‰ respectively. Among these inpatients, there were 61 eases of medieal patients and 14 eases of surgical patients, and most were youths and farmers. Conclusions HIV infection rate was increasing year by year. Most inpatients whose HIV-1 antibody was positive were in the phase of AIDS. Therefore, it＇s very necessary to execute routine testing for inpatients and outpatients who need special examination for early diagnosis of HIV infection.