^(18)F-FDG PET/CT对霍奇金淋巴瘤患者化疗后无事件生存的预测价值被引量：2

Fluorodeoxyglucose positron emission tomography-computed tomography after doxorubicin-bleomycin-vinblastine-dacarbazine chemotherapy predicts event-free survival in Hodgkin's lymphoma

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摘要目的:评估18氟-氟代脱氧葡萄糖-正电子发射计算机断层显像(fluorine-18fluorodeoxyglucose positron emission tomogra phy,18F-FDG PET/CT)对接受4个周期阿霉素、博来霉素、长春新碱、达卡巴嗪(ABVD)方案化疗的霍奇金淋巴瘤(Hodgkin's lympho ma,HL)患者预后的预测价值。方法:回顾分析2005年8月至2009年7月共62例初治的霍奇金淋巴瘤患者在接受4个周期ABVD方案化疗后18F-FDG PET/CT的检查结果,并与3年无事件生存率(EFS)、3年总生存率(OS)进行比较,评价其对接受4个周期AB VD方案化疗的霍奇金淋巴瘤患者无事件生存的预测价值。结果:治疗结束后,PET/CT阳性患者18例,其中11例患者(61.1%)治疗失败,PET/CT阴性患者46例,其中5例患者(11.4%)治疗失败,PET/CT阳性组的治疗失败率显著高于阴性组(P<0.01)。PET/CT阳性组和PET/CT阴性组患者的3年EFS分别是44.4%和81.8%(P<0.01),单因素分析显示PET/CT是霍奇金淋巴瘤患者3年EFS的独立预测因素(P<0.01)。结论:PET-CT是预测HL患者在接受4个周期ABVD方案化疗后EFS的可靠方法。 Objective： To evaluate the prognostic value of fluorodeoxyglucose （＇SF-FDG） positron emission tomography-computed tomography （PET/CT） after four cycles of chemotherapy using doxorubicin, bleomycin, vinblastine, and dacarbazine （ABVD） for Hodgldn＇s lymphoma （HL） patients. Methods： The data of 62 HL patients were retrospectively analyzed between August 2005 and July 2009. All patients underwent standard ABVD therapy. After four cycles of ABVD, the patients were evaluated with ~SF-FDG PET/CT. The prognostic value of 18F-FDG PET/CT in HL was analyzed. Results： Treatment failure was seen in 11 of the 18 PET/CT-positive patients （61.1%） and in only 5 of the 46 PET/CT-negative patients （11.4%）. The treatment failure rate in PET/CT-positive patients was significantly higher than in the PET/CT-negative ones （P〈0.01）. The three-year event-free survival （EFS） was 44.4% for PET/CT-positive patients and 81.8% for PET/CT-negative ones （P〈 0.01）. Univariate survival analysis revealed that ~F-FDG PET/CT was the independent predictive factor of three-year EFS for patients with HL （P〈0.01）. Conclusion： After four cycles of ABVD chemotherapy, PET/CT is found to be an independent predictor of EFS in HL. However. due to the limited number of patients in this stud,/, the conclusion needs to be confirmed.

作者任旭升王华庆钱正子周世勇张会来孟祥睿赵静王平

机构地区天津医科大学附属肿瘤医院淋巴肿瘤科

出处《中国肿瘤临床》 CAS CSCD 北大核心 2013年第4期225-228,共4页 Chinese Journal of Clinical Oncology

关键词霍奇金淋巴瘤 18氟-氟代脱氧葡萄糖正电子发射计算机断层显像预后 Hodgkin＇s lymphoma, fluorine- 18 fluorodeoxyglucose, positron emission tomography, prognosis

分类号 R733.1 [医药卫生—肿瘤]

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