超声微泡对射频消融效果影响的实验研究

Effects of microbubble on ultrasound guided frequency ablation

目的探讨超声微泡造影剂对射频消融效果的影响及应用价值。方法对20只活体兔肝分别以无造影剂及术中造影行射频消融术，评价气化区显示效果和消融时间，并测量气化区、术后造影缺损区及大体病理的大小，分析其相关性。结果加入微泡造影剂不影响射频消融的范围，但气化区形态更规则稳定，而且与凝固灶范围呈高度相关，同时可使施加射频时间明显缩短。结论射频消融中加入微泡造影剂有助于识别消融区范围，可预防消融区周围脏器及血管受损。

Objective To explore the effects of a microbubble agent （SonoVue） on radiofrequency ablation（RFA）. Methods Twenty rabbits underwent RFA with or without SonoVue on two areas per rabbit liver. SonoVue were injected in bolus intravenously in 0.1 ml/kg. The morphology of hyperechogenic area were observed by conventional ultrasonography. The size of RFA lesions and ablation time were measured. The correlation was analyzed between hyperechogenic area and ablation size. Results Microbubbles didn＇t change the size of RFA lesions. However, with the addition of SonoVue to ablation, the morphology of hyperechogenic area was showed more regular and stable, and hyperechogenic area and ablation size were well correlated （ r = 0.849, P = 0.000）. Besides, the ablation time was much shorter （ P 〈0.05）. Conclusions The addition of SonoVue to ablation improve the prediction of ablated areas and reduce the ablation time, therefore it might be useful to prevent the unfavorable ablation of adjacent organs and vessels.