摘要
目的:探讨幽门螺旋杆菌(Helicobacter pylori,Hp)感染与胃癌患者侵袭转移及血浆核黄素水平的关系。方法:采用Warthin-starry组织染色法、快速尿素酶试验及14C-UBT检测Hp感染。采用高效液相色谱法检测胃癌患者的血浆核黄素水平。结果:Hp感染胃癌组浆膜侵袭率与淋巴结转移率分别为62.5%和75%,高于无Hp感染胃癌组14.3%和42.9%(P<0.001,P=0.001 1)。胃癌无浆膜侵袭组和无淋巴结转移组血浆核黄素水平分别为1.870 6 ng/mL和2.381 1 ng/mL,高于浆膜侵袭组、淋巴结转移组(分别为0.733 1 ng/mL和0.795 0 ng/mL),两组血浆核黄素水平差异有统计学意义(P=0.013,P=0.046)。胃癌无HP感染组的血浆核黄素水平(1.667 4±0.370 09)ng/mL高于Hp感染组(1.220 7±0.177 27)ng/mL,血浆核黄素水平差异有统计学意义(P=0.043)。结论:Hp感染可能会影响胃癌患者预后和血浆核黄素水平。
Objective:This study aims to explore the relationship amongHelicobacter pylori infection, invasion and metastasis of gastric carcinoma, and plasma riboflavin level. Methods: The Warthin-Starry method, rapid urease test, and14 C-urea breath test were used to detect H. pylori infection. High-performance liquid chromatography was used to detect the level of riboflavin in gastric carcinoma plasma. Results: The incidence of serosal invasion and lymph node metastasis in gastric carcinoma patients with H. pylori infection (62 .5% and 75 %,re -spectively) was significantly higher than that in gastric carcinoma patients without infection ( 7.7% and42 .8%, respectively;P〈0.001, P=0.00 1 1). The levels of plasma riboflavin in gastric cancer patients without serosal invasion and without lymph node metastasis were 1.8706 and 2.381 1 ng/mL, respectively, which are higher than those in gastric cancer patients with serosal invasion and lymph node metastasis (0.733 1 and 0.795 0 ng/mL, respectively). Statistically significant differences in plasma riboflavin level were found between the two groups ( P=0.013, P=0.046). The level of plasma riboflavin in gastric cancer patients without H. pylori infection (1.667 4 ng/mL ± 0.370 09 ng/mL) was higher than that in gastric cancer patients with H. pylori infection (1.220 7 ng/mL ± 0.177 27 ng/mL) ( P=0.043). Conclusion:H. pylori infection may affect the prognosis of patients with gastric cancer and plasma riboflavin level.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2013年第3期153-156,共4页
Chinese Journal of Clinical Oncology
关键词
胃癌
幽门螺旋杆菌
核黄素
gastric carcinoma, helicobacter pylori, riboflavin