1Milich DR,Jones JE, Hughes JL et al. Is a function of the secreted hepatitis B e antigen to induce immunologic tolerance in utero? [J].Proe Natl Acad Sci USA, 1990,86:6599.
2Milieh DR, Jones JE, McLachlan A et al.Distinction between immunogenicity and tolerogenicity among HBcAg T cell determinants:: influence of peptideMHC interaction[J] .J Immunol, 1989,143:3148.
3Milich DR,Jones JE,Hughes JL et al. Role of T cell tolerance in the porsistence of hepatitis B virus infection[J] .J Immunother,1993,14:226.
4Reifenbeag K, Deutschle T, Wild J et al. The hepatitis B virus e antigen cannot pass the murine placenta efficiently and does not induce CIL immune tolerance in H-2b mice in utero[J],Virology,1998,243:45.
5Milieh DR, MeLachlan A, Raney AK et al. MHC - dependent autoantibody in HBeAg tranagenic mice elicited with self T cell peptides and inhihited with nonself peptides[J].Proc, Natl Acad Sci USA, 1991,88:4348.
6Milich D R,Peterson D L,Schodel F et al. Preferential recognition of hepatitis B nucleocapsid antigens by Th1 or Th2 cells in epitope and major histocompatibility oomples dependent[J] .J Virol, 1995,69:2776.
7Paul W E and Soder R A.Lymphocyts responses and cytokines[J].Cell,1994.76:241.
8Milich DR. Influence of T-helper cell subsets and crossregulation in hepatitis B virus nfection [J].J Viral Hepat, 1997,4(suppl.2)48.
9Maruyama T.Thomton GB,lino S et al. Cse of anti-peptide antibodies for the desigh of antigen-specific immune comples assays[J].J Immunol Methods, 1992,155:65.
10Maruyama T, Melachlan A,lino S et al. The serology of chrmic hepatitis B infection reviaited [J],J Clin Invest, 1993.91:2586.
2Papatheodoridis GV, Hadziyannis SJ. Diagnosis and management of pre-core mutant chronic hepatitis B. J Viral Hepatol,2001, 65:241-249
3Dumpis U, Mendy M, Hill A, et al. Prevalence of FIBV core promoter/precore/core mutations in Gambian chronic carriers.J Med Virol, 2001, 65:664-670
4Lohn HF, Weber W, Schlaak J, et al. Proliferative response of CD4^+ cells and hepatitis B virus clearance in chronic hepatitis with or without hepatitis B e-minus hepatitis B virus mutants.Hepatology, 1995, 22:61-68
5Tu H, Xiong SD, Trepo C, et al. Frequency of hepatitis Bvirus e-minus mutants varies among patients from different areas of China. J Med Virol, 1997, 51:85-89
6Wang YM, Ng WC, Lo SK, et al. Detection of preS/S gene mutants in chronic hepatitis B carriers with concurrent hepatitis B suface antibody and hepatitis B surface antigen. Gastroenterology, 1999, 34:600-606
7Heijtink RA, van Bergen P, van Roosmalen MH, et al. Anti-HBs after hepatitis B immunization with plasma derived and recombinant DNA-derived vaccine: binding to mutant HBsAg.Vaccine, 2001, 9:3671:3680.
9Yuan Min Wang,Wee Chit Ng,Su Kong Lo. Detection of pre-S/S gene mutants in chronic hepatitis B carriers with concurrent hepatitis B surface antibody and hepatitis B surface antigen[J] 1999,Journal of Gastroenterology(5):600~606