1Davis HL, Michel ML,Whalen RG, et al. DNA - based inmamizination induces continuous secretion of hepatitis B surface antigen and high levels of clrcularing antibody[J].Hum Mol Cene,1993,2(11) : 1847.
2Davis HL,Mccluskie MT, Gerin JL,et al. DNA vaccine for hepatits B: Evidence for immunogericity in chinpanzees and comparsion with other vaccines[J].Proc Natl Acad Sei USA, 1996,93(14) :7213.
3Prince AM,Whalen R, Brotman B, et al. Succesaful nucleic acid based immunisation of newborn chimpansees against hepatitis B virus [J]. Vaccine,1997,15(8) :916.
4Geissler M, Tokushige K. Wands J, et al. Cellular and humoral immune response to hepatitis B virus structural proteins in mice following DNA- based immunisation [J]. Castroenterology, 1997,112,1307.
5Triyantnl M.Jilbert AR. Qiso M.et al. Protective effeicacy of DNA vaccines against Dudk hepatitis B virus infection[J].J Virol, 1998.72(1) :84.
6bargne SL,Maryline M.Grand HL,et al.In vivo induetion of specific cytotorie T lymphocytea in mice and rheaus mscaques immunized with DNA vector encoding and HIV epitope fused with hepatitis B surface antigen[J].Virology,1998,240:304.
7Wikl J, Gruner B, Metzger K, et al. Polyvalent vaccination against hepartits B surface and core antigen using a dicistronicn expression plasmid[J]. 1998,16(4):353.
8Chow YH,Chiang BL,Lee YL, et al. Development of Th1 and Th2 populations and immune respanses to hepatitis B virus DNA vaccines can be modulated by codelivery of various cytokine genes[J].J Immunol, 1998,160(3):1320.
9Geissler M,Schirmbeck R, Reimann,J,et al. Cytakines and epatitis B virus DNA co-immunisations enhence cellulur and humctal immune reaponses to the middle but not to the large hepatitis B vires smface in mice[J].Hepatology,1998,28(1):202.
10Robinson A. DNA based vacciaes: new poesibilities for disease preveation and treatment [J].Can Mod Assoe J, 1995,152(10) : 1629.