MAPKs通路在MSCs的增殖及向成骨细胞分化过程中的作用

Effect of MAPKs pathways on proliferation and differentiation of osteoblasts by MSCs

间充质干细胞(MSCs)是一种多潜能成体干细胞,在体外诱导剂的作用下能向成骨细胞分化。在MSCs向成骨细胞分化过程中,受到MAPKs、BMPs、Notch和Wnt等多种信号通路的调控。其中MAPKs信号通路研究比较深入,近年来研究表明,在MAPKs信号通路的5种途径中,ERKs、p38MAPK和JNKs途径参与了成骨细胞增殖和分化的信号转导。现对MAPKs通路与其参与的MSCs增殖和成骨分化过程简要综述。

Mesenchymal stem cells （MSCs） are adult stem cells with pluripotency, which can differentiate into osteoblasts induced by osteogenie medium in vitro. The development of osteoblast differentiation is regulated by multiple signaling pathways, including MAPKs, BMPs, Notch, and Wnt. Among them, the MAPKs signaling pathways have been studied thoroughly. Researches in recent years reveal that 3 out of 5 pathways, including ERKs, p38MAPK, and JNKs, are involved in the signal transduetion in osteoblastic proliferation and differentiation. This paper briefly reviews the effect of MAPKs pathways on osteohlast proliferation and differentiation.