中药甘草对大鼠肠平滑肌运动的影响

Effect of licorice on the intestinal smooth muscle motility in rats

目的观察甘草对大鼠肠道平滑肌运动的影响,了解甘草与胃肠运动之间的关系。方法实验分成正常组、甘草制成煎剂4、8、16、32、64 g/kg剂量组,每日1次灌胃给药。末次给药1 h后观察大鼠胃半排时间;采用灌胃给予炭末,测定胃推进率。结果甘草煎剂剂量大小对大鼠小肠蠕动有直接的影响,较小剂量对大鼠小肠的推进功能有抑制作用,较大剂量对大鼠的肠推进有促进作用。

Objective To observe the impact of licorice on the intestinal smooth muscle motility in rats, and to understand the relationship between licorice doses and changes of intestinal motility. Methods One hundred and twenty Wistar rats weighing （200 ± 10） g, male：femal （e = 1 ） ： 1, were used in this study. The rats were divided into normal control and experimental groups. The experimental groups receiving licorice decoction 4, 8, 16, 32, 64 g/kg daily in gastric gavage for consecutive 5 days, respectively, 10 rats in each group. The gastric half-emptying time was determined at one hour after the last time of licorice administration. The rate of stomach advancing was observed using oral administration of charcoal. Results and conclusions Licorice decoction has direct effect on the intestinal motility in rats. Licorice in low doses exerts inhibitory effect and in high doses promotes the small intestinal propulsion movement in rats.