摘要
目的:应用MRS和DTI观察脑胶质瘤放疗前、后肿瘤周围水肿区变化。方法:31例病理诊断明确的脑胶质瘤术后患者,分别在放疗前、后行MRI平扫+增强+MRS+DTI检查。分析肿瘤瘤周水肿区代谢物比值的变化[胆碱(Cho)/肌酐(Cr)、Cho/N-乙酰天门冬氨酸(NAA)、NAA/Cr]及部分各向异性(fractional anisotropy,FA)值、ADC值变化。结果:放疗后瘤周水肿区Cho/Cr、Cho/NAA、NAA/Cr值较放疗前下降,其中Cho/Cr差异有统计学意义(P<0.05),Cho/NAA、NAA/Cr值差异无统计学意义(P>0.05);瘤周水肿区域放疗后FA值升高(P>0.05),ADC值下降(P<0.05)。结论:MRS及DTI能显示肿瘤水肿区放疗后的早期变化,较早反映放疗效果。
Objective: To evaluate the MR spectroscopy and diffusion-tensor imaging in the radiotherapy of glioma peritumoral edema region. Methods.. 31 patients with gliomas confirmed by pathology after partial surgical resection underwent routine MR1 contrast-enhanced scanning, MRS and DTI pre and post-radiotherapy (pre-RT and post-RT). The regions of interest(ROD were placed on peritumoral brain edema region and normal white matter region respectively. The Cho/Cr, Cho/NAA, NAA/Cr rati- os, FA and ADC values were calculated automatically from both pre-RT and post-RT image sequences. Results: Compared to pre-RT, the ratios of Cho/Cr,Cho/NAA, NAA/Cr decreased in regions of peritumoral edema, there were significant differences in Cho/Cr and no significant differences in Cho/NAA, NAA/Cr. FA increased(P〉0. 05) and ADC values decreased(P〈0.05). Conclusion: MRS and DTI can early provide important information about effect of radiotherapy.
出处
《中国中西医结合影像学杂志》
2013年第1期4-6,14,共3页
Chinese Imaging Journal of Integrated Traditional and Western Medicine
关键词
神经胶质瘤
瘤周水肿
放射疗法
磁共振波谱学
弥散张量成像
Glioma
Peritumoral edema region
Radiotherapy
Magnetic resonance spectroscopy
Diffusion tensor imaging