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慢性乙型病毒性肝炎患者血清可溶性细胞间粘附分子-1作用的初步探讨 被引量：1

The Study of the role of Soluble Intercellular Adhesion Molecule-1 in Patients with Chronic hepatitis B
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摘要 探讨可溶性细胞间粘附分子 - 1(sICAM 1)在慢性乙型肝炎中的作用及临床意义。应用酶联免疫吸附试验检测 5 6例慢性乙型肝炎患者血清sICAM 1水平。慢性乙型肝炎患者血清sICAM 1水平明显高于正常人水平 ,且随着肝细胞损伤程度的加重而升高 ,与T细胞亚群无相关性。血清sICAM - 1水平可反映慢性乙型肝炎患者的病情及肝细胞坏死程度 ,不能直接影响其细胞免疫功能。 To evealuate the biologic role of soluble intercellular adhesion molecule 1(sICAM 1) in chronic hepatitis B(CHB).serum sICAM 1 was detected by ELISA in 56 patients with CHB.Serum sICAM 1 level in CHB was notably higher than in NC(P<0.01/0.05) and paralleled with the serious degree of liver damage,there were no correlations with CD + 4+,CD + 8 or the ratio of CD + 4/CD + 8.Serum sICAM 1 level increase in CHB and consist with liver damage,it can not influence cellular immune function.
作者 尹洪竹 刘金星 曹治宸 李兵顺 汤慧华 冯忠军
机构地区 河北医科大学第三医院
出处 《临床肝胆病杂志》 CAS 北大核心 2000年第4期230-231,共2页 Journal of Clinical Hepatology
关键词 可溶性细胞间粘附分子-1 慢性乙型肝炎 细胞免疫 Soluble intercellular adhesion molecule 1 cellular immune Chronic hepatitis B
分类号 R512.62 [医药卫生—内科学]
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参考文献4

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同被引文献12

  • 1CLAYTON A,STEADMAN R. ICAM-1 interactions in the renal interstitium:a novel activator of fibroblasts during nephritis[J]. Histol Histopathol, 1999,14(3) : 861-70.
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  • 3MORIYAMA M,MATSUMURA H,SHIODA J,et al. Measurement of human intercellular adhesion molecule 1 in the blood is useful for predicting the occurrence of hepatocellular carcinomas from chronic hepatitis C and liver cirrhosis[J]. Intervirology, 2006,49(6) : 327-38.
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临床肝胆病杂志
2000年 第4期

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