法莫替丁片剂和胶囊剂体外溶出度考察

Study on Dissolution Rate of Famotidine from Its Tablets and Capsules

目的 对国内四个生产厂家的法莫替丁片及胶囊进行了体外溶出度对比实验，观察其体外溶出度。方法 采用１９９５年版药典二部转蓝法，以人工胃液为介质，用紫外分光光度法测定含量。结果 各产品溶出度均符合规定，但溶出常数经ｔ法检查，Ｄ样品Ｔ５０与其它产品差异显著（Ｐ〈０．０５）。结论 剂型影响溶出度。

Objective:To study the dissolution rates of famotidine(Fam)from its tablets and capsules,produced by four Pharmaceutical factories.Methods:The concentrating basket,Using 0 1mol/L hydrochloricacid as solvent.Results:The dissolution of T 50 of sample D has significant difference from other samples (P<0 05).conclusions:The factors influencing the dissolution rates of Fam were discussed.