愤怒情志与儿茶酚胺氧位甲基转移酶基因多态性的关系

Association analysis between val158Met polymorphism of catechol-O-methyltransferase gene and anger trait

目的:探讨正常大学生愤怒情志特质与儿茶酚胺氧位甲基转移酶(COMT)基因多态性之间的关系。方法:根据状态特质愤怒表达量表2(STAXI-2)特质怒得分,选择225例高特质怒受试者和221例低特质怒受试者进行对照研究,应用连接酶特异检测技术(LDR)测定研究对象COMT(V158M)G/A基因位点的等位基因和基因型。结果:COMT基因V158M位点的3种基因型(A/A,A/G和G/G)在高、低特质怒组正常大学生中的分布差异无统计学意义,且3种基因型受试者的愤怒表达及愤怒控制程度差异无统计学意义。结论:COMT基因V158M位点的多态性与愤怒情志特质无关联。

Objective： To investigate the association between Va1158Met polymorphism of catechol-O-rnethyltransferase （COMT） gene and anger trait in healthy Chinese college students. Methods： According to the state-trait anger expression inventory-l] （STAXI-2）, the Val158Met polymorphism of COMT gene was tested in 225 students with high trait anger score and 221 students with low trait anger score by Ligase detection reaction（LDR）. Results： The distribustions of alleles or genotypes（A/A, A/G and G/G） of COMT gene are not significantly different between the two groups. There are not significant relations between COMT genotypes and the score of anger-expression and anger-control. Conclusion： For these healthy Chinese college students in this study, we can＇t assure the association between Val158Met polymorphism of COMT gene and anger trait.