泮托拉唑治疗老年NSAIDs相关消化性溃疡出血的效果观察

The clinical effieacy of pantoprazole for bleeding peptic ulcers associated with NSAIDs in elderly patients

目的观察泮托拉唑治疗老年非甾体类抗炎药（NSAIDs）相关消化性溃疡出血的临床效果。方法随机选取在我院就诊的老年NSAIDs相关消化性溃疡出血患者100例，分为观察组和对照组。对照组使用法莫替丁静脉滴注，观察组使用泮托拉唑静脉滴注。对比两组止血效果、再出血及不良反应情况。结果经一个疗程治疗，观察组止血总有效率为94％，对照组总有效率为82％，两组止血效果差异有统计学意义（P〈0．05）；观察组再出血率为6％，显著低于对照组的22％，差异有统计学意义，P〈0．05。结论泮托拉唑治疗老年NSAIDs相关消化性溃疡出血安全有效，并发症少。

Objective To observe the clinical efficacy of pantoprazole in the treatment of NSAIDs-relat- ed bleeding peptic ulcers in elderly patients. Methods 100 elderly patients with NSAIDs-related bleeding pep- tic ulcers were randomly selected and then divided into study group and control group. The control group re- ceived intravenous infusions of famotidine, and the study group received intravenous infusions of pantoprazole. The effect of hemostasis, re-bleeding, and adverse reactions were compared between the two groups. Results After a course of treatment, the total effectiveness rate for hemostasis was 94% in the study group and 82% in the control group, with a statistical difference （ P〈0.05 ）. The rate of re-bleeding rate was significantly lower in the study group than in the control group （6% vs. 22%, P〈0.05 ）. Conclusions Pantoprazole is safe and effective in the treatment of elderly patients with NSAIDs-related bleeding peptic ulcer.