摘要
目的探讨β-连环蛋白及p120-连环蛋白(p120 ctn)在尖锐湿疣及宫颈鳞癌组织中的表达及生物学意义。方法采用免疫组化SP法分别检测β-catenin、p120 ctn在尖锐湿疣和宫颈鳞癌中的表达。结果β-catenin、p120 ctn在尖锐湿疣和宫颈鳞癌组织中的表达程度和阳性表达率均显著低于正常对照组,有显著性差异(P<0.01);尖锐湿疣组和宫颈鳞癌组β-catenin和p120 ctn的表达程度比较有显著性差异(P<0.01)。结论β-cate-nin、p120 ctn在尖锐湿疣和宫颈鳞癌的发病机制中起一定的作用,可作为宫颈癌前病变的参考指标。
Objective It is to explore the expression and its biologic significances of β-catenin and p120 ctn in the tissue of condyloma acuminatum and cervical squamons cell carcinoma. Methods The expressions of β- catenin and p120 ctn in the tissue of condyloma acuminatum and cervical squamous cell carcinoma were determined respectively by immuohistochemical SP method. Results The expression degree and positive expression rate of β- eatenin and p120 ctn in the tissue of eondyloma acuminatum and cervical squamous cell carcinoma were significantly lower than that of normal control group, and the differ- ences were significant（P 〈0.01 ）. There was significant differences in the expressions of β-catenin and p120 ctn between condyloma acuminatum group and cervical squamous cell carcinoma group. Conclusion β-eatenin and p120 ctn plays a role in condyloma acuminatum and cervical squamous cell carcinoma＇ s pathogenesis. They can be used as reference indexes for cervical precancerous lesions.
出处
《现代中西医结合杂志》
CAS
2013年第8期806-808,共3页
Modern Journal of Integrated Traditional Chinese and Western Medicine
