艾滋病合并隐球菌脑膜炎18例临床分析

Acquired immunodeficiency syndrome(AIDS) complicated with cryptococcal meningitis:clinical analysis of 18 cases

目的 提高对艾滋病 (AIDS)合并隐球菌脑膜炎的认识。方法 对赤道几内亚巴塔地区医院 18例AIDS合并隐球菌脑膜炎患者进行临床综合分析。结果 18例AIDS合并隐球菌脑膜炎患者的临床主要表现为 :发热、剧烈头痛、极度乏力、肢体痛、脑膜刺激征及消瘦与脱水等。脑脊液 (CSF)培养均为新型隐球菌生长 ;涂片及隐球菌多糖荚膜抗原 (ELISA法 )检测的阳性率分别为 77 8% (14/ 18) ,94 4% (17/ 18)。结论 隐球菌脑膜炎为AIDS常见机会性感染及主要致死病因之一。

Objective To enhance understanding of AIDS-associated cryptococcal meningitis.Methods 18 patients with AIDS-associated cryptococcal meningitis were analyzed.Results The major symptoms of these patients were fever, severe headache and tiredness, neck stiffness, loss of weight and dehydrate.The positive ratio of the cultures and india ink smears and the cryptococcal polyscaccharide capsular antigen(ELISA) in cerebrospinal fluid(CSF) were 100 0% (18/18) , 77 8%(14/18) and 94 4%(17/18), respectively.The mortality of the patients was 83 3%(15/18). Conclusion The cryptococcal meningitis is the common opportunistic infection and one of the major death causes in AIDS.