小肠细菌过度生长和肠易激综合征关系的探讨

Relationship between intestinal bacterial overgrowth and the irritable bowel syndrome

目的 探讨小肠细菌过度生长与肠易激综合征发病中的关系。方法 用乳果糖氢呼气试验测定 49例腹泻及便秘型肠易激综合征病人口 -回盲瓣通过时间 ,并了解其阳性发生率 ;对其中 10例阳性者给普瑞博思治疗1周 ,进行治疗前后比较。结果 在肠易激综合征病人中腹泻及便秘型口 -回盲瓣通过时间较对照组延长 (P <0 0 5 ) ,阳性发生率无差别 (P >0 0 5 ) ,治疗后口 -回盲瓣通过时间改善明显 (P <0 0 5 ) ,症状改善。结论 小肠功能紊乱可导致小肠细菌过度生长 ,并可能是肠易激综合征发病因素之一。

Objective To study the relationship between the irritable bowel syndrome and bacterial overgrowth in the intestines.Methods Forty-nine cases of irritable bowel syndrome presenting as diarrhea or constipation were tested by the lactose-functose hydrogen breath test to determine the oral-cecal passage time and positive rate was noted.Of the cases with positive tests ten were selected for treatment with prepulsid for one week,and the pre-and post-treatment passage times were compared.Results In regard to passage time both diarrhea and constipation types of the irritable bowel syndrome showed prolongation compared with controls(P<0 05),no difference in the positive rates(P>0 05),and improvement after treatment compared with pre-treatment,diarrhea was also improved by treatment.Conclusion Intestinal dysfunction can lead to bacterial overgrowth in the intestines,which can be a cause of the irritable bowel syndrome.