期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

一个含苯并咪唑环的酰氨基硫脲NMR研究 被引量：2

An NMR Study on An Acylthiosemicarbazide Containing Benzimidazole Moiety
下载PDF
导出
摘要 该文合成了一个新的在医药方面具有潜在应用价值的含苯并咪唑环的酰氨基硫脲化合物,即4-(4-甲氧基苯基)-1-[2-(4-硝基苯氧基甲基)-苯并咪唑-1-基]甲酰基氨基硫脲,并利用元素分析、IR和NMR对其结构进行了表征.通过NOESY谱确定了其两种异构体(A和B)的构型,并利用2DNMR技术对它们的1H NMR和13C NMR谱进行了全归属,给出了相应的偶合常数和两种异构体的含量. A novel compound with potential pharmaceutical applications, 4-（4-methoxyphenyl）- 1-{[2-（4-nitrophenoxymethyl）-benzimidazol-1 yl] methyl }-carbonylthiosemicarbazide （ 1 ） was synthesized. Its structure was determined by elemental analysis, IR and NMR techniques. The existence of two isomers of compound 1 were confirmed by NOESY spectroscopy. The ^1 H and ^13C NMR signals of the isomers were assigned completely using 2D NMR techniques, and the corresponding coupling constants and the tautomeric ratios of isomers were also reported.
作者 李英俊 邱文龙 许永廷 罗潼川 于洋 邵昕
机构地区 辽宁师范大学化学化工学院
出处 《波谱学杂志》 CAS CSCD 北大核心 2013年第1期131-139,共9页 Chinese Journal of Magnetic Resonance
基金 Natural Science Foundation of Liaoning Province(20102126)
关键词 核磁共振(NMR) 归属 2D NMR 4-(4-甲氧基苯基)-1-[2-(4-硝基苯氧基甲基)-苯并咪唑-1-基]甲酰基氨基硫脲 构型分析 NMR, assignment, 2D NMR, 4-（4 methoxyphenyl）-1-{[-2-（4-nitrophenoxymeth-yl）-benzimidazol-l-yl]methyl} carbonylthiosemicarbazide, conformational analysis
分类号 O482.53 [理学—固体物理]
  • 相关文献

参考文献15

  • 1Ansari K F, Lal C, Khitoliya R K. Synthesis and biological activity of some triazole-bearing benzimidazole derivatives[J]. J Serbian Chem Soc, 2011, 76(3): 341-352.
  • 2Dua R, Sonwane S K, Srivastava S K, et al. Conventional and greener approach for the synthesis of some novel substituted-4-Oxothiazolidine and their 5-Arylidene derivatives of 2-Methyl-benzimidazole: antimicrobial activities[J]. J Chem Pharm Res, 2010, 2(1): 415-423.
  • 3Zhang S S, Zhan T R, Cheng K, et al. Simple and efficient synthesis of novel glycosyl thiourea derivatives as potential antitumoragents[J]. Eur J Med Chem, 2008, 43: 2 778-2 783.
  • 4Mostafa M R, Mohamed A O, Abdel-Momen M E, et al. Synthesis and antitumor activity of 1-substituted- 2-methyl-5-nitrobenzimidazoles[J]. Bioorgan Med Chem, 2006, 14: 7 324-7 332.
  • 5Canan K, Gülgün A,Ozbey S, et al. Synthesis and antioxidant properties of novel N-methyl-1,3,4-thiadiazol-2-amine and 4-methyl-2H-1,2,4-triazole-3(4H)-thione derivatives of benzimidazole class[J]. Bioorgan Med Chem, 2008, 16: 4 294-4 303.
  • 6Sengupta P, Puri S C, Chokshi A H, et al. Synthesis, preliminary biological evaluation and molecular modeling of some new Heterocyclic inhibitors of TACE[J]. Eur J Med Chem, 2011, 46: 5 549-5 555.
  • 7Wang J L, Zhang J, Zhou Z M, et al. Design, synthesis and biological evaluation of 6-substituted aminocarbonyl benzimidazole derivatives as nonpeptidic angiotensin Ⅱ AT-1 receptor antagonists[J]. Eur J Med Chem, 2012, 49: 183-190.
  • 8Hernandez L F, Hernández C A, Castillo R, et al. Synthesis and biological activity of 2-(trifluoromethyl)-1H-benzimidazole[J]. Eur J Med Chem, 2010, 45: 3 135-3 141.
  • 9Mavrova A T, Vuchev D, Anichina K, et al. Synthesis, antitrichinnellosis and antiprotozoal activity of some novel thieno[2,3-d]pyrimidin-4(3H)-ones containing benzimidazole ring[J]. Eur J Med Chem, 2010, 45: 5 856-5 861.
  • 10Siwek A, Stczek P, Stefńska J. Synthesis and structure-activity relationship studies of 4-arylthiosemicarbazides as topoisomerase Ⅳ inhibitors with Gram-positive antibacterial activity. Searchfor molecular basis of antibacterial activity of thiosemicarbazides[J]. Eur J Med Chem, 2011, 46: 5 717-5 726.

二级参考文献52

共引文献23

同被引文献18

  • 1缪振春,吴文铸,冯锐.选择性远程DEPT NMR技术用于萜类生物碱的结构测定[J].有机化学,1993,13(2):145-149. 被引量：2
  • 2Chinese Academy of Science Flora of China Editorial Board(中国科学院中国植物志编辑委员会).Flora of China(中国植物志)[M].Beijing(北京):Science Press(科学出版社),1988.
  • 3Hegde V R, Borges S, Pu Hai-yan, et al. Semi-synthetic aristolactams-inhibitors of CDK2 enzyme[J]. Bioorg Med Chem Lett, 2010, 20:1 384-1 387.
  • 4Zhang J, Xiao Y S, Feng J T, et al. Selectively preparative purification of aristolochic acids and aristololactams from arlstolochia plants[J]. J Pharm Biomed Anal, 2010, 52 ~ 446- 451.
  • 5Dong S W, Shang M Y, Wang X, et al. Chemical constituents isolated from Sarurna henryi[J]. Journal of Chi- nese Pharmaceutical Sciences(JCPS), 2009, 18: 34- 38.
  • 6Iwashina T, Marubashi W, Suzuki T. Chaleones and flavonols from the Chinese species Saruma henryi[J]. Bio- them Syst Ecol, 2002, 30:1 101-1 103.
  • 7Kupchan S M, Merianos, J J. The isolation and structural elucidation of novel derivatives of aristolochic acid from aristolochia indiea[J]. J Org Chem, 1968, 33: 3 735-3 738.
  • 8Priestap H A. Seven aristololactams from aristololchia argentina[J]. Phytoehenristry, 1985, 24: 849-852.
  • 9Priestap H A. ^13C NMR spectroscopy of aristolochic acids and aristololactams[J]. Magn Reson Chem, 1989, 27: 460-469.
  • 10江海鹏,蒋先旺,张许,刘买利.天然孕甾烷-17(20)-烯中C-17位双键构型的快速测定[J].波谱学杂志,2011,28(1):93-98. 被引量：1

引证文献2

二级引证文献2

波谱学杂志
2013年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部