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The Role of MicroRNAs in Neural Stem Cells and Neurogenesis 被引量：11

The Role of MicroRNAs in Neural Stem Cells and Neurogenesis
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摘要 Neural stem cells give rise to neurons through the process of neurogenesis, which includes neural stem cell proliferation, fate deter- mination of new neurons, as well as the new neuron＇s migration, maturation and integration. Currently, neurogenesis is divided into two phases： embryonic and adult phases. Embryonic neurogenesis occurs at high levels to form the central nervous system. Adult neurogenesis has been consistently identified only in restricted regions and occurs at low levels. As the basic process for embryonic neurodevelopment and adult brain maintenance, neurogenesis is tightly regulated by many factors and pathways. MicroRNA, short non-coding RNA that regulates gene expression at the post-transcriptional level, appears to be involved in multiple steps of neurogenesis. This review summarizes the emerging role of microRNAs in regulating embryonic and adult neurogenesis, with a particular emphasis on the proliferation and differentiation of neural stem cells. Neural stem cells give rise to neurons through the process of neurogenesis, which includes neural stem cell proliferation, fate deter- mination of new neurons, as well as the new neuron＇s migration, maturation and integration. Currently, neurogenesis is divided into two phases： embryonic and adult phases. Embryonic neurogenesis occurs at high levels to form the central nervous system. Adult neurogenesis has been consistently identified only in restricted regions and occurs at low levels. As the basic process for embryonic neurodevelopment and adult brain maintenance, neurogenesis is tightly regulated by many factors and pathways. MicroRNA, short non-coding RNA that regulates gene expression at the post-transcriptional level, appears to be involved in multiple steps of neurogenesis. This review summarizes the emerging role of microRNAs in regulating embryonic and adult neurogenesis, with a particular emphasis on the proliferation and differentiation of neural stem cells.
作者 Fen Ji Xiaohui Lv Jianwei Jiao
机构地区 Institute of Zoology
出处 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2013年第2期61-66,共6页 遗传学报（英文版）
基金 supported by the grants from the Chinese Academy of Sciences(No.XDA01020301) the Hundred Talent Program
关键词 MICRORNA Neural stem cell Embryonic neurogenesis Adult neurogenesis MicroRNA Neural stem cell Embryonic neurogenesis Adult neurogenesis
分类号 Q522 [生物学—生物化学]
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参考文献64

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同被引文献96

  • 1张新生,刘超群.hsa-miR-1-5p靶基因预测及功能分析[J].中国循环杂志,2018,0(S01):15-16. 被引量：1
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  • 4Kazutoshi Takahashi,Koji Tanabe,Mari Ohnuki,Megumi Narita,Tomoko Ichisaka,Kiichiro Tomoda,Shinya Yamanaka.Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors[J]. Cell . 2007 (5)
  • 5Shiwu Dong,Bo Yang,Hongfeng Guo,Fei Kang.MicroRNAs regulate osteogenesis and chondrogenesis[J]. Biochemical and Biophysical Research Communications . 2012 (4)
  • 6JinZhang,QishengTu,Lynda FBonewald,XiHe,GaryStein,JaneLian,JakeChen.Effects of miR‐335‐5p in modulating osteogenic differentiation by specifically downregulating Wnt antagonist DKK1[J]. J Bone Miner Res . 2011 (8)
  • 7Ling Guo,Robert C.H. Zhao,Yaojiong Wu.The role of microRNAs in self-renewal and differentiation of mesenchymal stem cells[J]. Experimental Hematology . 2011 (6)
  • 8Kazutoshi Takahashi,Shinya Yamanaka.Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors[J]. Cell . 2006 (4)
  • 9Ian Chambers,Douglas Colby,Morag Robertson,Jennifer Nichols,Sonia Lee,Susan Tweedie,Austin Smith.Functional Expression Cloning of Nanog, a Pluripotency Sustaining Factor in Embryonic Stem Cells[J]. Cell . 2003 (5)
  • 10Arshak R. Alexanian,Qing-song Liu,Zhiying Zhang.Enhancing the efficiency of direct reprogramming of human mesenchymal stem cells into mature neuronal-like cells with the combination of small molecule modulators of chromatin modifying enzymes, SMAD signaling and cyclic adenosine monophosphate levels[J]. International Journal of Biochemistry and Cell Biology . 2013 (8)

引证文献11

二级引证文献39

Journal of Genetics and Genomics
2013年 第2期

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