粘附分子表达与肝癌侵袭转移的关系

Adhesive molecule expression in relation to invasion and metastasis in human hepatocellular carcinoma

目的 :探讨粘附分子E cadherin和CD44v6表达与肝细胞癌 (HCC)侵袭转移的关系。方法 :用免疫组化法检测 6 6例人肝细胞癌组织中E cadherin和CD44v6的表达。结果 :侵袭转移倾向高危组 2 2例HCC组织中E cadherin和CD44v6的阳性率分别为 18 2 % (4 / 2 2 )和 6 8 2 % (15 / 2 2 ) ;侵袭转移倾向低危组的 44例HCC组织中 ,E cadherin和CD44v6的阳性率分别为5 4 5 % (2 4/ 44 )和 2 5 0 % (11/ 44 )。E cadherin表达与HCC的侵袭转移倾向呈负相关 (P <0 0 1) ,而CD44v6表达与HCC的侵袭转移倾向呈正相关 (P <0 0 1) ,且这两种粘附分子在肝癌中表达呈负相关 (P <0 0 1)。结论 :粘附分子表达与肝癌侵袭转移密切相关 ,检测E

Purpose To investigate the correlation of adhesive molecule expressions with potential of invasion and metastasis in human hepatocellular carcinoma(HCC). Methods Immunohistochemical method was used to detect E cadherin and CD44v6 expression in 66 cases of HCC. Results In high potential of invasion and metastasis group, the positive rates of E cadherin and CD44v6 were 18 2%(4/22) and 68 2%(15/22), and in low potential group, 54 5%(24/44)and 25 0%(11/44),respectively. There was a reverse correlation between E cadherin expression and the tumor invasive and metastastic potential in HCC ( P <0 01) and a positive correlation between CD44v6 expression and the potential. Moreover, there was a reverse correlation between the E cadherin and CD44v6 expression ( P <0 01) in HCC. Conclusions These data show a correlation between the adhesive molecule expression and the potential of invasion and metastasis in HCC. E cadherin and CD44v6 expression may be a prognostic indicator in HCC.