肾炎灵冲剂对家兔慢性肾小球肾炎的作用

Effects of Shenyanling on chronic glomerulonephritis in rabbits

目的 :观察肾炎灵冲剂对家兔慢性肾小球肾炎的作用。方法 :用大鼠肾小球基底膜和弗氏佐剂 ,给家兔注射 ,复制出慢性肾小球肾炎模型。给肾炎灵冲剂 ,观察尿蛋白、血清尿素氮、肌酐、血清白蛋白、球蛋白及肾组织的病理学改变。结果 :肾炎灵冲剂可剂量依赖性地降低尿蛋白(P<0 .0 5)、血清尿素氮 (P<0 .0 5)、肌酐 (P<0 .0 5)的水平 ,提高血清白蛋白的水平 (P<0 .0 5) ,减轻肾小球病变。结论

? Objective:To sutdy the effects of Shenyanling on chronic glomerulonephritis in rabbits.Methods:Rat glomerular base membrane (GBM) and Freund′s adjuvant were injected into rabbits subcutaneously or intracutaneously to build the Steblay nephritis model.Shenyanglin was administered.Kidney function was evaluated by measuring urine protein,urea nitrogen,creatinine,albumin and globulin in serum as well as the histopathological changes of kidney were observed.Results:Compared with model group,Shenyanling could dosedependently reduce the level of the urine protein,urea nitrogen and creatinine in serum and the damage of kidney;while,the serum albumin could maintain the normal level (P<005).Conclusion:Shenyanling has protective effects on chronic glomerulonephritis in rabbits.