膀胱癌浸润转移与纤维蛋白含量表达相关性研究

Study on the relationship between infiltration and transfer of bladder carcinoma and the fibrin level

目的 :探讨膀胱癌浸润、转移机理。方法 :应用琼脂糖单向扩散法和免疫酶染色技术 (ABC法 )检测膀胱癌病人血清及膀胱癌组织中纤维结合蛋白 (FN)的含量及分布。结果 :膀胱癌病人血清中 FN含量明显低于正常对照组 ,统计学处理差异非常显著 (P<0 .0 1 ) ,膀胱癌组织中 FN表达于细胞基质中 ,少部分表达于细胞膜表面 ,且转移癌与非转移癌阳性表达差异显著。结论 :FN含量与膀胱癌浸润。

? Objective:To explore the mechanism of infiltration and transfer of bladder carcinoma.Methods:Ager single diffusion method and immunoenzyme technique were adopted to determine the level and distribution of fibrin in serum and tissues of bladder carcinoma.Results:Fibrin level in patients with bladder carcinoma significantly decreased than that in control (P<01).In tissues of bladder carcinoma,most part of FN was expressed in cellular matrix,and a little FN was on the surface of cell membrane.Positive expression in transfer bladder carcinoma significantly decreased than that in nontransfer bladder carcinoma.Conclusion:FN level relates to the infiltration and transfer in bladder carcinoma patients.