帕金森病患者疲劳和抑郁的相关性研究

Observations on fatigue, depression and quality of life in patients with Parkinson＇s disease

目的探讨帕金森病患者疲劳和抑郁的相关性。方法选取帕金森病患者56例，疲劳严重度量表（FSS）评价患者的疲劳程度，Hamilton抑郁量表（HAMD）评价患者的抑郁程度，帕金森病生活质量问卷（PDQL）评价患者的生活质量，并进行UPDRSm、Hoehn-Yahr分期评定、改良Webster评分。结果患者疲劳的发生率为71．4％（40／56）。HAMD评分、PDQL总分与患者疲劳相关，偏相关系数分别为0．451（P〈0．01）、-0．346（P〈0．05）。无抑郁患者疲劳发生率较低，为27．3％，抑郁组疲劳发生率较高，其中轻度、中度和重度抑郁疲劳发生率分别为75％，100％，100％。结论疲劳感是帕金森病患者抑郁的重要表现，也可以是独立于抑郁之外的非运动症状，同样影响着帕金森病患者的生活质量。

Objective To identify the association between fatigue and depression in Parkinson＇s disease （PD）. Methods 56 PD patients were enrolled in this study. The degree of fatigue was measured by Fatigue Severity Scale （FSS）. Hamilton Depression Scale （ 24 items ） was used to evaluate the degree of depression. PD Quality of Life Questionnaire （PDQL） were tested to evaluate the quality of fife in PD patients. While other clinical information such as Unified Parkinson＇s Disease Rating Scale （UPDRS） Ⅲ, Hoehn-Yahr Scale and modified Webster Scale were investigated. Results The incidence of fatigue in this group is 71.4% （40/56）. Score of HAMD and PDQL exhibited a significant correlation to patients＇ fatigue, coefficient of partial correlation was 0. 451 （ P 〈 0. 01 ）, - 0. 346 （ P 〈 0. 05 ）. The incidence of fatigue in non-depressive patients was low, 27.3 %. While in depressive patients, the incidence of fatigue is relatively high, for mild depression 75%, moderate depression 100%, severe depression 100% respectively. Conclusions Fatigue is a prominent symptom of depression in PD patients, sometimes independent of depression also influencing the patients＇ quality of life.