烯醇硅醚的环丙烷化:一种有用的合成工具

The Cyclopropanation of Silyl Enol Ethers:An Important Synthetic Tool

本文主要介绍了利用改进的Simmons-Smith反应制备饱和、不饱和脂肪族、脂环族羰基化合物的三甲基烯醇硅醚的环丙烷化反应和不同条件下硅氧基环丙烷产物的开环反应以及烯酮的三甲基烯醇硅醚的双环丙烷化反应在合成中应用。

This article mainly discusses the trimethylsilyl enol ethers of both saturated and unsaturated aliphatic or alicyclic carbonyl compounds , when submitted to cyclopropanation by an improved simmons - simth reactions , lead to siloxcyclopropane derivatives, which are useful synthetic intermediates. Depending on the starting material and the reactions subsequently applied, the following may be carried out the α - monomethylation of saturated aldehydes and ketones ; the specific α - or α＇ - monomethylation of cycloalkenones ; the synthesis of cyclopropylcyclo- propanols,cyclopropyketones and double cyclopropanation products.