血清IV型胶原在肝纤维化诊断中的意义

Diagnostic value of serum type IV collagen in hepatic fibrosis

目的 研究血清IV型胶原(IVC)在诊断肝纤维化中的意义。方法 以放免分析法检测正常对照者(NC)及慢性肝病患者血清IVC浓度，并与Ⅲ型前胶原(PCⅢ)比较。结果 各慢性肝病组血清IVC、PCⅢ浓度均显著高于NC组(P均＜0..01)。血清IVC浓度在重度慢性肝炎(CH)组显著高于轻、中度CH组(P均＜0..01)，活动性肝硬变(LC)组显著高于静止性LC组(P＜0..05)。血清IVC与PCⅢ在CH组及LC组中均呈显著性正相关(CH组r=0.7023,LC组r=0.5878,P均＜0..001)。结论 血清IVC浓度可反映肝纤维化的活动程度。

Objective\ To study the diagnostic value of serum type IV collagen(IVC) in hepatic fibrosis.Methods\ Serum IVC levels w ere detected by using radioimmunoassay(RIA) and were compared with serum type Ⅲ procollagen(PCⅢ) levels in normal controls(NC) and patients with chronic liver diseases.Results\ Serum IVC and PCⅢ levels in patients with chro nic liver diseases were all much higher than those in NC(P＜0.01,tot ally).Serum IVC level in severe chronic hepatitis(CH) group was significantly higher than those in mild and median CH groups (P＜0.01 totally),and that in active liver cirrhosis(LC) group was significantly higher than that in static LC group (P＜0.05).There were significant positive correlatio n between serum IVC level and serum PCⅢ level both in CH group and in LC gro up(in CH r=0.7023,in LC r=0.5878,P＜0.001).Conclusio n Serum IVC level could reflect the activity of hepatic fibrogenesi s.