萎缩性舌炎与维生素B12缺乏之间的关系

Atrophic glossitis is attributed to cobalamin deficiency

目的:分析萎缩性舌炎的病因,探索萎缩性舌炎与血清维生素B12、叶酸水平之间的关系。方法:回顾分析1979年1月—2010年6月收治的213例萎缩性舌炎的病因,检测2010年9月—2011年8月新纳入的萎缩性舌炎患者的血清维生素B12、叶酸水平及血细胞分析。采用SPSS16.0软件包对所得数据进行t检验。结果:213例萎缩性舌炎患者中,45.5%(97/213)与大细胞性贫血或红细胞巨幼变有关;新纳入的72例患者中,69.4%(50/72)与维生素B12缺乏有关。维生素B12缺乏组患者平均血清叶酸水平高于维生素B12正常组。结论:维生素B12缺乏是导致大细胞性贫血及萎缩性舌炎的共同病因,也是引起萎缩性舌炎的主要原因,萎缩性舌炎可能是维生素B12缺乏的早期表现。

PURPOSE： To analyze the causes of atrophic glossitis （AG） and to explore the relationship between AG and serum cobalamin, folate levels. METHODS： A total of 213 patients with AG treated from Jan.1979 to Jun. 2010 were analyzed for the causes of AG. Serum cobalamin, folate levels and complete blood count were tested in newly enrolled AG patients from Sep. 2010 to Aug. 2011. All data were analyzed with SPSS 16.0 software package for Student＇s t test. RESULTS： There were 97 AG patients （45.4%） suffering from megaloblastie anemia （MA）/macrocytosis. Among the 72 newly enrolled AG patients, fifty had eobalamin deficiency. Meanwhile, serum folate levels were increased in eobalamin deficiency group. CONCLUSIONS： Cobalamin deficiency is the common cause both of MA/macrocytosis and AG, also may be the main cause of AG. Furthermore, AG may be the early clinical manifestation of cobalamin deficiency. Supported by National Natural Science Foundation of China（81170967）.