摘要
During the last several decades, significant progress has been made in understanding the roles of B cells inimmunity and autoimmunity. B-cell development, occurring in the bone marrow, is a complex dynamic process involving immunoglobulin （Ig） gene rearrangement and B-cell receptor （BCR） expression. Early progenitor B （pro-B） cells initiate DNA rearrangement at their Ig heavy chain loci, resulting in the synthesis of μ-chains in the cytoplasm and the assembly of the precursor B-cell receptor （pre-BCR）. Following successful rearrangement of light chain genes, these precursor B （pre-B） cells differentiate into immature B cells when whole IgM mole- cules are expressed as the functional BCR on the cell surface.
During the last several decades, significant progress has been made in understanding the roles of B cells inimmunity and autoimmunity. B-cell development, occurring in the bone marrow, is a complex dynamic process involving immunoglobulin （Ig） gene rearrangement and B-cell receptor （BCR） expression. Early progenitor B （pro-B） cells initiate DNA rearrangement at their Ig heavy chain loci, resulting in the synthesis of μ-chains in the cytoplasm and the assembly of the precursor B-cell receptor （pre-BCR）. Following successful rearrangement of light chain genes, these precursor B （pre-B） cells differentiate into immature B cells when whole IgM mole- cules are expressed as the functional BCR on the cell surface.
