1Bachar O, Adner M, Uddman R, et al.Toll-like receptor stimulation induces airway hyper-responsiveness to bradykinin, an effect mediated by JNK and NF-kappa B signaling pathways[J}.Eur J Immunol, 2004, 34(4): 1196-1207.
5Poltorak A, He X, Smirnova I, et al.Defective LPS signaling in C3H/ HeJ and C57BL/10ScCr mice: mutations in TLR4 gene[J].Science, 1998, 282(5396): 2058-2088.
6Pastor C M, Pugin J, Kwak B, et al.Role of Toll-like receptor 4 on pancreatic and pulmonary injury in a mice model of acute pancreatitisassociated with endotoxemia[J].Crit Care Med, 2004, 32(8): 1759-1763.
7Michelsen K S, Wong M H, Shah P K, et al.Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and ahers plaque phenotype in mice deficient in apolipoprotein E[J].Proc Natl Acad SciUSA, 2004, 101(29): 10679-10684.
8Bjtrkbaeka H, Kunjathoor V V, Moore K J, et al.Reduced atheroselerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways[J].Nat Med, 2004, 10(4): 416-421.
9Howell K W, Meng X, Fullerton D A, et al.Toll-like receptor 4 mediates oxidized LDL-induced macrophage differentiation to foam cells[J].J Surg Res, 2011, 171(1): 27-31.
10Ding Y, Subramanian S, Montes V N, et al.Toll-like receptor 4 deficiency decreases atherosclerosis but does not protect against inflammation in obese low-density lipoprotein receptor-deficient mice[J]. ArteriosclerThrombVascBiol, 2012, 32(7): 1596-1604.
6[3]Devereux RB,Roman MJ,de Simone G.Relations of left ventricular mass to demographic and hemodynamic variables in American Indians:the Strong Heart Study[J].Circulation,1997,96:1416-1623.
7[4]Chobanian AV,Bakris GL,Black HR,et al.seventh report of the joint national committee on prevention,detection,evaluation,and treatment of high blood pressure[J].Hypertension,2003,42:1206-1252.
8[5]Medzhitov R,Preston-Hurlburt P,Janeway.A human homologue of the Drosophila Toll protein signals activation of adaptive immunity[J].Nature,1997,388:394-397.
9[6]Kathrin S,Michelsen,Terence M,et al.TLR signaling:an emerging bridge from innate immunity to atherogenesis[J].The J of Immu,2004,173:5901-5907.
10[8]Sever PS,Dahlof B,Poulter NR,et al.Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations,in the Anglo-Scandinavian Cardiac Outcomes Trial 2 Lipid Lowering Arm(ASCOT-LLA):a multicentre randomized controlled trial[J].Lancet,2003,361:1149-1158.