酒精性肝病发生及其与严重程度的相关性研究

Relevant research of occurrence and severity of alcoholic liver diseases

目的探讨影响酒精性肝炎（AH）及酒精性肝硬化（ALC）疾病发生相关因素及严重程度。方法按照2010年中华医学会肝病学分会脂肪肝和酒精肝病学组通过的临床诊断标准，分析241例AH及ALC患者的临床资料。结果ALC患者日饮酒量、饮酒年限、总饮酒量与AH患者差异有统计学意义（P〈0．01）。ALC组中工人、农民及无业等低收入嗜酒者所占比例（48．39％）明显高于AH组（25．58％）（P〈0．叭）。实验室检查示ALC组AST／ATJT比值（2．63±4．74）显著高于AH组（1．01±0．52）（P〈0．01）；ALC组TG[（1．33±1．24）mmol／L]和CHOL[（3．14±1．25）mmol／L]显著低于AH组TG[（2．29±1．60）mmol／L]和CHOL[（4．27±0．79）mmol／L]（P〈0．01）。结论酒精性肝病的发生及严重程度与饮酒量、饮酒年限及工作情况有关；AST／ALT比值、TG及CHOL值与酒精性肝病严重程度相符。

Objective To investigate the disease occurrence-related factors and severity of alcoholic hepatitis （AH） and alcoholic liver cirrhosis （ALC）. Methods According to the clinical diagnostic criteria that were passed by the 2010 Chinese Society of Fatty Liver Hepatology and alcoholic liver disease study group, the clinical data of 241 AH and ALC patients were analyzed. Results The amount of liquor taken daily, the time limit of drinking, and total amount of liquor taken in ALC patients were significantly different from those in AH patients （ P 〈0. 01 ）, respectively. In ALC patients, the proportion （48.39%） of workers, peasants, and unemployed low-income alcoholics was significantly higher than that （25.58%） in AH patients （ P 〈0. 01 ）. Laboratory tests showed the AST/ALT ratio in the ALC group （2. 63 ±4. 74） was significantly higher than that in the AH group （ 1.01 ± 0. 52 ） （ P 〈 0.01 ） ; TG [ （ 1.33 ± 1.24 ） mmol/L] and cholesterol （CHOL） [ （3.14 ± 1.25 ）mmol/L] in ALC group were significantly lower than TG [ （2. 29 ± 1.60） mmol/L] and CHOL [ （4. 27 ±0. 79）mmol/L] in the AH group （ P 〈0. 01 ）. Conclusions Alcoholic liver disease occurrence and severity were related to the amount of liquor taken, the time limit of drinking, and the work ; AST/ALT ratio, TG and CHOL values were consistent with the severity of alcoholic liver disease.