美托洛尔联合丹参注射液治疗乙型肝炎肝硬化性心肌病的临床研究

A clinical study of metoprolol with salviae miltiorrhizae treatment on cirrhotic cardiomyopathy resulting from Hepatitis B

目的观察美托洛尔联合丹参对乙型肝炎肝硬化性心肌病(CCM)的治疗作用。方法将84例CCM患者随机分为A组、B组、C组和D组,每组均21例,A组采用常规治疗,B组采用常规治疗+美托洛尔治疗,C组采用常规治疗+丹参治疗,D组采用常规治疗+美托洛尔+丹参治疗,疗程4周,检测肝功能,以彩色多普勒超声测定左室射血分数(LVEF)及舒张早期/晚期最大血流速度(E峰/A峰,E/A)比值。结果 A组肝功能指标好转,与治疗前比较差异无显著性(P>0.05)。LVEF、E/A比值与治疗前比较差异无显著性(P>0.05)。B组肝功能指标好转,与治疗前比较差异无显著性(P>0.05),E/A比值与治疗前比较差异有显著性(P<0.01),C组肝功能指标好转,与治疗前比较差异有显著性(P<0.01),LVEF,E/A比值与治疗前比较差异无显著性(P>0.05)。D组患者肝功能指标好转和LVEF、E/A比值上升程度无论1周、2周和4周明显优于A组、B组和C组(P<0.01)。结论美托洛尔联合丹参对CCM有较好的治疗作用。

[ Objective ] To explore the effects of Metoprolol with Salviae mihiorrhizae in treatment of patients with Cirrhotic Cardiomyopathy （CCM） Resuhing from Hepatitis B. [Methods] A total of 84 patients with CCM were randomly divided into group A（n =21） treated with routine method and group B（n =21） treated with Metoprolol and rou- tine method. Group C（n =21） were treated with Salviae mihiorrhizae and routine method. Group D（n =21） were treated with Metoprolol, Salviae miltiorrhizae and routine method. Treated for four weeks. The value of left venhicular ejection fraction （LVED and the ratio of early diastolic/late peak velocity（E/A） were measured by color Doppler. [ Resuits ] The liver function in group A was not significantly improved compared with those before treatment （P 〉0.05）, while the levels of LVEF and the ratio of E/A were not significantly improved compared with those before treatment （P 〉0.05）. The liver function in group B was not significantly improved compared with those before treatment （P 〉 0.05）, while the levels of LVEF and the ratio of E/A were significantly higher compared with those before treatment（P〈0.01）. The liver function in group C was significantly improved compared with those before treatment （P 〉0.05）. While the levels of LVEF and the ratio of E/A were not significantly improved compared with those before treatment （P 〉0.05）. The liver function, LVEF, and the ratio of E/A in group D were significantly higher compared with those of group A, B and group C（P 〈0.01）. [ Conclusion] The results suggested that Metoprolol with Salviae miltiorrhizae can play a therapeutic role in CCM.