北方地区成人脂肪肝危险因素的病例对照研究

Case-control Study on the Risk Factors of Fatty Liver Disease in Northern People

目的:探索北方地区成人脂肪肝的危险因素。方法:采用病例对照研究对294名病例和655名对照的相关资料进行非条件Logistic回归分析。结果:超重(OR=6.3,95%CI=4.4,8.9)、肥胖(OR=16.9,95%CI=9.9,28.9)、腹型肥胖(OR=2.9,95%CI=1.9,4.5)、血脂异常(OR=2.1,95%CI=1.5,3.0)及ST-T改变(OR=1.6,95%CI=1.0,2.3)与脂肪肝的患病明显相关(P<0.05)。摄入肉类较多、高盐饮食及自觉压力较大均为脂肪肝的危险因素,其OR值分别为1.5(95%CI,1.0,2.1)、1.5(95%CI,1.1,2.1)及1.4(95%CI,1.0,2.2)。在家就餐超过5d为脂肪肝的保护因素,OR为0.6(95%CI,0.4,0.9)。结论:脂肪肝的发生与代谢性疾病及生活方式密切相关。

[Objective] To investigate the risk factors for fatty liver disease in northern people. [Method] Data of case-control study including 294 cases and 655 controls were analyzed using non-conditional logistic regression. [Result] Overweight （ OR =6. 3, 95% CI =4.4, 8.9）, obesity （ OR = 16. 9, 95% CI = 9.9, 28.9）, abdominal obesity （ OR = 2.9, 95% CI = 1.9, 4. 5 ）, dyslipidemia （ OR -- 2. 1, 95% CI = 1.5, 3.0 ） and ST-T changes （OR = 1.6, 95% CI = 1.0, 2. 3 ） were significantly associated with the risk of fatty liver disease （ P 〈 0. 05）. High intake of meat, high-salt diet and pressure were the risk factors of fatty liver disease, and the OR values were 1.5 （95% CI, 1.0, 2. 1 ）, 1.5 （95% CI, 1.1,2. 1 ） and 1.4 （95% CI, 1.0, 2. 2）, respectively. Eating at home more than 5 d was a protective factor for fatty liver and the OR value was 0. 6 （95% CI 0. 4, 0. 9） . [Conclusion] The occurrence of fatty liver is closely associated with metabolic diseases and unhealthy lifestyle.