2-苯基环丙烷羧酸丙酯异构体色谱分离过程研究

Separation of propyl 2-phenylcyclopropanecarboxylate stereomers

由于具有生物活性的对映体在手性环境中如生物体内 ,其物理、化学性质往往相差很大 ,甚至相反 ,因此 ,研究它们的分离与检测在现代药物化学、生物化学、农业化学、合成化学等领域非常重要。通过对 2 苯基环丙烷羧酸丙酯在多种手性固定相上分离过程的研究 ,建立了一种可同时直接分离、测定其 4种立体异构体 (两组对映体 )的方法。

Chemical and physical properties of enantiomers with physiological activity are usually very different or even opposite .So it is very important to investigate their separation and determination method in the fields of modern medicamentous ,biological ,agricultural ,synthetic chemistry and so on . A new method of separating and determining four stereomers of propyl 2 phenylcyclopropanecarboxylate was found by investigation of the separation of the stereomers on Chiral stationary phases . Quick and efficient enantiomer separation can be achieved by selecting suitable chiral stationary phases and separation condition.