膀胱肿瘤二次电切术前灌注吡柔比星的效果观察

The effect observation of preoperative instillation of pirarubicin in the second transurethral resection of bladder tumor

目的探讨膀胱肿瘤二次电切术前灌注吡柔比星的效果。方法 50例诊断为膀胱尿路上皮癌患者分为二次电切组(TURB-t组)及二次电切+吡柔比星术前灌注组(TURB-t+THP组)各25例。TURB-t组行常规二次电切,TURB-t+THP组术前30分膀胱内灌注40 mg吡柔比星,再行二次电切。结果所有患者均随访24月,TURB-t组6例进展、16例复发,TURB-t+THP组3例进展、11例复发;1、2年无疾病进展率TURB-t+THP组分别为97%和92%,TURB-t组分别为93%和81%;1、2年无疾病复发率TURB-t+THP组分别为80%与59%,TURB-t组分别为67%与42%,差异均有统计学意义(P<0.05)。结论二次电切术前灌注吡柔比星能改善膀胱尿路上皮癌患者预后。

Objective To investigate the effect of pirarubiein in the second transurethral resection of bladder tumor. Methods Fifty patients with urothelial carcinoma were divided into two groups：one was the second transurethral resection group（ TURB-t group） and another was TURB-t plus pirarubiein instillation group（ TURB-t＋THP group）. In the TURB-t group routine TURB-t was applied while in the TURB-t＋THP group ,40 mg of pirarubiein was instilled into bladder before operation. Results All patients were followed- up for 24 months after operation. In the TURB-t group,6 patients progressed and 16 patients suffered from recurrence while in the TURB-t＋THP group 3 patients progressed and 11 patients suffered from recurrence. The differences were statistically significant. Con- clusion The preoperational instillation of pirarubicin could improve the patients＇ prognosis with bladder-urothelial carcinoma.