老年人重症急性胰腺炎继发感染的影响因素分析

The analysis of factors influencing secondary infection in severe acute pancreatitis in senior patients

目的探讨老年人重症急性胰腺炎(severe acute pancreatitis,SAP)继发感染的影响因素。方法收集2005～2009年我院收治的156例老年SAP患者的临床资料,按照有无继发感染分为继发感染组(38例)和无感染组(118例),对两组间的相关临床参数进行分析比较。结果继发感染组住院时间和病死率均高于无感染组(P<0.05)。多变量Logisitic回归分析显示多器官功能衰竭(OR=5.17,95%CI 1.22～25.68,P<0.05)、入院时WBC计数(OR=6.72,95%CI 9.71～38.67,P<0.05)是SAP继发感染的独立影响因素。结论老年人SAP继发感染增加患者的病死率及住院时间,多器官功能衰竭、入院时WBC计数是其继发感染的独立影响因素。

Objective The aim of the study to explore the predisposing factors which were associated with the secondary infec- tion in senior patients with severe acute pancreatitis （SAP）. Methods The clinical data of 156 old patients, who suffered from SAP from the year 2005 to 2009 in our hospital ,were analyzed. The patients were divided into 2 groups with（ n = 38 ）and without secondary infection （ 118 cases）. Results The in hospital mortality rate and hospitalization duration of the infection group are respectively higher and longer than those of the non-infection group （P 〈 0. 05 ）. Multiple Logistic models analysis revealed that multiple system organ fail- ure （ OR = 5.17,95 % CI 1.22 - 25.68, P 〈 0.05 ） and admission WBC count （ OR = 6. 72,95 % CI 9.71 - 38.67, P 〈 0. 05 ） were inde- pendent predisposing factors. Conclusions The senior patients with SAP complicated by the secondary infection increase both in hos- pital mortality rate and hospitalization duration. Multiple system organ failure and admission WBC count are independent predisposing factors for the secondary infection.