瑞舒伐他汀对老年兔心肌梗死左室重构和心功能的影响

Influence of rosuvastatin in left ventricular remodeling and cardiac function after myocardial infarction in rabbits

目的观察瑞舒伐他汀对老年兔心肌梗死后左室重构和心功能的影响。方法老年雄性新西兰大白兔18只随机分为假手术组、心肌梗死组、瑞舒伐他汀组各6只,梗死模型建立后予瑞舒伐他汀从胃肠道灌输4周所在的组为瑞舒伐他汀组。制模前后分别测定左室舒张末期内径(LVDD)、左室收缩末期内径(LVDS)、左心室短轴缩短率(LVFS)和左心室射血分数(LVEF),术后测量肌细胞瘢痕和肌细胞凋亡指数(AI)。结果手术组与假手术组比较,梗死成功后心肌梗死组和瑞舒伐他汀组的LVFS、LVEF明显减小,但在某种程度上LVDD、LVDS显著增大(均P<0.01);在心肌梗死制造模型成功后的14、28d瑞舒伐他汀组LVDS低于心肌梗死组(P<0.05和P<0.01),然而LVFS和LVEF均明显高于心肌梗死组(均P<0.01);在梗死模型建立后28天瑞舒伐他汀组心肌瘢痕指数小于心肌梗死组(P<0.05);假手术组AI显著低于舒伐他汀组和心肌梗死组(P<0.01),但心肌梗死组明显高于瑞舒伐他汀组(P<0.05)。结论瑞舒伐他汀对老年兔心肌梗死后的心肌重塑与心功能的有良性的影响,其机制可能是为减少梗死的面积,增强了心肌耗氧量;这一研究将会对人类诊断和预防心肌梗死的恶化提供了新的指南和依据。

Objective To observe and study correlation influence of rosuvastatin in left ventricular remodeling and cardiac function after myocardial infarction in rabbits. Methods Olderly male New Zealand white rabbits were random divided into control group, myocardial infarction group and rosuvastatin group. Myocardial infarction combination rosuvastatin group were established the left anterior descending coronary artery ligation after infarction model, infarction after the establishment of the model to red easy cutting statin calcium from the gastrointestinal tract infusion 4 weeks group for Rosuvastatin group. Before and after molding respectively, left ventricular end-diastolic diameter （LVDD）, left ventricular end-systolic diameter （LVDS）, left ventrieular short axis shorten rate （LVFS） and left ventricular ejection fraction （LVEF） were measured, postoperation muscle cell scar index and muscle cell apoptosis index （AI） was measured. Resuits The scores and sham operation group comparison, after the success of the infarction myocardial infarction group and red easy cutting statin group of LVFS, LVEF was decreased, but in a way LVDD, LVDS significantly increased （P 〈0.01）; In myocardial infarction manufacturing model after the success of 14 and 28 d red easy cutting statin group LVDS below myocardial infarction group （P（0. 05 and 0.01）, however LVFS and LVEF were significantly higher than that of myocardial infarction group （P〈O. 01）; In the infarction model after the establishment of the 28 d Rosuvastatin group myocardial scarring index less than myocardial infarction group （P（0.05） ; sham operation group AI significantly lower than easy cutting statin group and myocardial infarction group （P%0.01）, but the myocardial infarction group is obviously higher than that of the red easy cutting statin group （P%O. 05）. Conclusion Rosuvastatin for elderly rabbit after myocardial infarction myocardial remodeling and cardiac function in a benign influence, its mechanism may be to reduce the area of infarction, enhance the myocardial oxygen consumptiom This research will provides a new guidelines and basis to the human diagnosis and prevent the deterioration of myocardial infarction.