高血压脑出血患者应激性高血糖与微创碎吸术后血清炎性细胞因子水平的相关性研究

Investigation of stress hyperglycemia and inflammatory cytokines in hypertensive cerebral hemorrhage after micro-injury operations

目的观察高血压脑出血患者应激性高血糖对微创碎吸术后血清细胞因子水平的影响。方法 80例高血压脑出血患者按入院24小时内血糖分为正常血糖组(56例)和高血糖组(24例),同时选10例健康人血清做对照,连续监测血清中肿瘤坏死因子α(TNFα)、白细胞介素6(IL-6)的动态变化。结果两组患者的TNFα、IL-6含量均高于健康对照组。正常血糖组患者其TNFα、IL-6含量达峰时间早。高血糖组患者TNFα、IL-6含量达峰时间较晚,且TNFα、IL-6水平较高。结论脑出血患者血浆炎性细胞因子水平水平升高与应激反应有关,且对预后产生不利影响。

Objective To investigate the effect of stress hyperglycemia on inilammatory cytosines m serum oi hypertensive cerebral hemorrhage after micro-injury operations. Methods 80 patients accepted micro-injury operation according their blood glucose with 24 hours after their enrollment were divided two groups., hyperglycemia group （n=24） and normoglycemia group （n= 56）. 10 serum samples of healthy persons were tested as control. The changes of TNFa, IL-6 were observed continuously. Results The levels of TNFa,II.-6 of patients are higher than that of healthy control. That of group hyperglycemia was higher than normoglycemia group. Patients＇ peak levels of TNFa,IL-6 of appeared earlier in hyperglycemia group than normoglycemia group. Conclusion There is a relationship between the high level of in- flammatory cytokines in serum and stress hyperglycemia and stress hyperglycemia makes the curative effect worse.