摘要
目的探讨丹参多酚酸盐治疗急性脑缺血患者的临床疗效。方法将96例急性脑缺血患者随机分为治疗1组、治疗2组、对照组,各32例,对照组采用常规治疗:抗血小板、脑保护剂及改善脑循环、血压控制等;治疗1组在常规治疗的基础上加用丹参多酚酸盐100 mg/d静脉滴注,共治疗14 d;治疗2组在常规治疗的基础上加用丹参多酚酸盐200 mg/d静脉滴注,共治疗14 d。测定治疗前后三组患者的神经功能缺失评分(NDS)和日常生活活动能力评分(ADL)。结果治疗1组治疗前后NDS为(21.65±3.75)、(17.75±2.74)分,治疗2组为(21.28±4.08)、(15.43±3.057)分,对照组为(21.50±3.66)、(18.53±3.63)分,三组NDS均降低(P<0.05),且治疗2组改善情况优于对照组(P<0.05)。治疗1组治疗前后ADL评分分别为(24.21±3.12)、(58.23±5.31)分,治疗2组为(28.25±4.82)、(59.23±8.54)分,对照组为(29.53±4.51)、(55.78±8.55)分。三组治疗后ADL评分明显升高,但治疗2组较对照组升高明显(P<0.05)。治疗2组总有效率(90.62%)高于对照组(68.75%)(P<0.05)。结论中剂量丹参多酚酸盐可显著改善急性脑缺血患者的病情,值得临床推广。
Objective To investigate the clinical effect of salt from salvia miltiorrhiza on patients with acute cerebral ischemia. Methods 96 patients with acute cerebral ischemia were randomly divided into 3 groups, group 1 ( n = 32, miltiorrhiza 100 mg/d) , group 2 ( n = 32, miltiorrhiza 200 mg/d ) and control group ( n = 32 ). All the groups were treated with routine treatment of antiplatelet, brain protestant, brain circulation improvement and blood pressure control. The treatment lasted for 14 d. Before and 14 d after treatment, the neurologic impairment analysis, activity of daily living scale (ADL) were checked. Results After treatment, the NDS of group 1, group 2 and control group de creased from (21.65 ±3.75),(21.28 ±4.08),(21.50 ±3.66) to (17.75±2.74),(15.43 ±3.057),(18.53± 3.63 ) respectively ( P 〈 0. 05 ) , in which, the improvement of group 2 was better than that of control group ( P 〈 0. 05 ) ; the ADL of group 1, group 2 and control group increased from (24. 21 ± 3. 12 ) , (28.25 ± 4. 82 ), (29. 53± 4. 51 ) to (58. 23± 5.31 ) , ( 59. 23 ±8.54) , (55.78 ±8.55 ) respectively ( P 〈 0. 05 ) , and the increase of group 2 was more sig nificant than that of control group( P 〈 0.05 ). There was significant difference in total effective rate between group 2 and control group ( 90. 62% vs. 68.75 % , P 〈 0. 05 ). Conclusion Middose of salt from salvia miltiorrhiza can im prove the symptom of patients with acute cerebral ischemia.
出处
《实用药物与临床》
CAS
2013年第2期114-116,共3页
Practical Pharmacy and Clinical Remedies
关键词
丹参多酚酸盐
急性脑缺血
Salt from salvia miltiorrhiza
Acute cerebral ischemia