摘要
细胞内钙超载在心房颤动(AF)的发生和维持中的作用被广泛关注。AF时快速心房率引起细胞内钙超载,细胞内钙通道的表达和功能改变,使AF维持。T型钙通道参与基础钙的调节,而心肌收缩时,L型钙通道在钙释放过程中起到触发作用。收缩期胞浆内90%的Ca2+由SR上的RyR2释放;舒张期胞浆内70%～75%的Ca2+由SR上的Ca2+-ATP酶摄取贮存。本文对AF时L型、T型钙通道以及SR上RyR2和Ca2+-ATP酶的表达和功能变化进行概述,为AF的防治提供更多的理论依据。
The role of intracellular Ca2 ＋ overload in the occurrence and maintenance of atrial fibrillation（AF） , and AF is widely concerned. The Ca2 ＋ overload caused by the increased atrial rate of AF leads to expressional and func- tional changes of Ca2 ＋ channels, which further induces the maintenance of AF. T-type Ca2 ＋ channel is mainly involved in the regulation of basic Ca2 ＋ levels, while L-type Ca2 ＋ channel plays a triggering role in the process of Ca2 ＋ release during cardiac contraction. 90% of intracellular Ca2 ＋ is released by ryanodine receptor 2 （ RyR2 ） on the sarcoplasmic reticulum（SR） during systole ;70% -75% is restored by Ca2＋ -ATPase on the SR during diastole. This article describes the expressional and functional changes of L-type and T-type Ca2 ＋ channels, RyR2 and Ca2 ＋ -ATPase on the SR in an overview, to orovide theoretical basis for AF orevention and treatment.
出处
《实用药物与临床》
CAS
2013年第2期151-154,共4页
Practical Pharmacy and Clinical Remedies
