抗分泌性腹泻药物的研究进展

Advance in Antisecretory Drugs for Diarrheal

病理性腹泻是人和动物常见疾病症状之一,长期以来控制腹泻是医学上一个重点。基于肠病原菌及其产物诱导肠道分泌的机理,许多学者开展了相应的调控研究。肠细胞仍是直接研究和开发新药的主要焦点,随着新靶位ENS和促分泌素等发现。

Infectious diarrhoea, particularly that due to pathogenic bacteria, is a major health problem worldwide. A variety of mechanisms have been identified by which enteropathogenic bacteria and their products can induce secretory processes in the intestine now. The major focus for many years has been the enterocyte （intracellular drug targets） and consequently this has been viewed as the most rewarding site for directing research and development into novel antisecretory agents. However, in re- cent years other secretory mechanisms have been discovered which inctude a role for endogenous secretagogues and the enteric nervous system.