男性相关因素对夫精宫腔内人工授精妊娠率的影响

Effect of male factors on intrauterine insemination pregnancy rate

目的:探讨在宫腔内人工授精(IUI)过程中男性相关因素对妊娠成功率的影响,为临床IUI治疗不育提供参考。方法:选取排除女方因素和双方因素所导致的219周期不育IUI的资料,统计分析其中男性相关因素(如年龄、学历、不育年限以及精子形态正常率、精液处理前后前向运动精子数等)与妊娠率的关系。结果:共行IUI治疗219周期,妊娠23例,周期妊娠率为10.5%。随着男方年龄增长,拥有正常精子形态的人群比例呈下降趋势,差异有统计学意义。40岁以上年龄组妊娠成功率低于其他组(P<0.05),高学历组妊娠成功率也较其他组低,但比较差异无统计学意义(P>0.05)。男方不育年限各分组中妊娠率比较差异无统计学意义(P>0.05)。精子形态率正常组的妊娠率稍高于异常组,IUI妊娠率随着精液处理前后的前向运动精子数的增加均有上升的趋势,但比较差异无统计学意义。结论:男方年龄对正常精子形态的影响有统计学意义,但是男方学历、不育年限、处理前后的前向精子总数以及精子形态学等对IUI成功率无明显影响。

Objective： To study the effect of male factors on the intrauterine insemination （IUI） pregnancy rate, and provide referencesfor the treatment of IUI. Methods： A retrospective analysis of 219 cycles were involved in the study. The IUI data of infertility due to female or both gender factors was excluded. Result： The overall pregnancy rate （PR） was 10. 5% （23/219）. The sperm morphology normal rate was decreased along with aging. And the PR of 〉 40 year-old group was lower than younger age groups. Highly educated group＇s PR was also lower than other education groups. No statistical difference was found relating to infertility duration. The PR of the spermmorphology normal rate normal group was higher than the abnormal group with the rise of the total motile sperms no matter before or after processed, cant found in them. Conclusion： Male＇s age affected negatively on sperm was found regarding male＇s age, education, infertility duration, total adv IUI pregnancy rate , and IUI PR was in a rising trend along although there was no statistically signifi- morphology, but no significant difference ancing sperms and sperm morphology to