脆性组氨酸三联体基因在舌癌中的表达及其意义——附126例检测报告

Study on expression of FHIT in oral tongue squamous cell carcinoma:a report of 126 cases

目的:探讨脆性组氨酸三联体(FHIT)基因在舌癌中的表达及意义。方法:采用免疫组织化学染色法分别检测126例舌癌组织(舌癌组)、39例以舌白斑为代表的癌前病变组织(癌前病变组)、30例正常舌黏膜组织(正常对照组)中的FHIT表达情况,并对其表达水平进行统计学比较。结果:FHIT在舌癌组、癌前病变组及正常对照组中的阳性表达率分别为54%、79%、100%,各组阳性表达率比较差异均有统计学意义(P<0.05)。不同分化程度舌癌组织中FHIT阳性表达率比较差异也具有统计学意义(P<0.05),其中高分化舌癌组织FHIT阳性表达水平最高,低分化表达水平最低。结论:舌癌组织和癌前病变组织中的FHIT表达下降,其改变可能与舌癌的发生有关,可能适用于舌癌检测。

Objective： To study the implication of FHIT in oral tongue squamous cell carcinoma （OTSCC）. Methods： The expression of FHIT was detected by immunohistochemical staining in lingual samples from 126 pa- tients with OTSCC, 39 patients with leukoplakia lingualis and 30 health subjects for analysis. Results： The positive rates of FHIT in OTSCC, precancerous lesions and normal tissues were 54% , 79% , 100% , respectively. Signifi- cant differences in positive rates of FHIT were observed among groups （ P 〈 0. 05 ）. The expression of FHIT in OTSCC was significant different among different differentiation, with the well-differentiated lesion expressing the highest and the poorly differentiated lesion expressing the lowest （ P 〈 0.05 ）. Conclusion： The result suggests that the change of the expression of FHIT is involved in the occurrence of the OTSCC. FHIT may be applicable to tongue cancer detection.