HPV单一感染与多重感染对宫颈病变影响的比较

Compare of the Influence on Cervical Lesion Between Single and Multiple HPV Genotype Infection

目的 :探讨单一高危HPV亚型与多重高危HPV亚型感染对宫颈病变的影响。方法 :选取2010年1月—12月在天津医科大学总医院妇科门诊就诊的有性生活史并出现临床症状的患者137例,比较患者细胞学、病理学结果出现的概率;比较单一高危HPV亚型与多重高危HPV亚型感染对宫颈病变影响的差别。结果:①在全部感染病例中,以20～49岁者居多,并且随着年龄的增长,感染率呈现下降趋势。②感染病例中,高危型别以HPV16感染率最高。③在宫颈高级别病变中,以HPV16感染率最高。④单一高危与多重高危HPV感染相比较,宫颈细胞学和病理学结果差异无统计学意义。⑤高低危混合HPV感染中低级别病变概率高于单纯高危HPV感染,而高级别病变则相反。结论:①与单一高危HPV亚型相比,多重高危HPV亚型感染对宫颈病变严重程度的影响不明显。②与单纯高危HPV亚型感染相比,高低危HPV亚型混合感染更多表现为低级别宫颈病变。

Objective ：To discuss the differences between the cervical lesions induced by single hr-HPV and multiple hr-HPV infection,by comparing the liquid-based cytology and biopsy pathological results of all the cases. Methods：Compare the probability of all the LCT and pathologic results. Compare the differences between the cervical lesions, which were induced by single hr-HPV and multiple hr-HPV infections. Results： （1）In all the infection cases,the most common age was from 20 to 49, and the incident rate went down along with the age increasing. （2）In all the infection cases, HPV16 was the most frequent type. （3）In all the cases of high grade cervical lesions ,HPV16 was the most frequent type.（4）Compare of the single hr-HPV and multiple hr-HPV infections, there were no significant differences between the cervical lesions. （5）CIN Ⅱ-Ⅲ lesions,which induced by pure hr-HPV infections were higher than mixed HPV infections,in opposition to low grade cervical lesions. Conclusions：（1）Compare with single hr-HPV infection,the cervical lesions,which induced by the multiple hr-HPV infections, is not obvious. （2）Compare with single hr-HPV infections, the mixed HPV infections induced more low grade cervical lesions.