HIF-1α与宫颈癌关系的Meta分析

The Relationship Between HIF-1α and Cervical Cancer:A Meta-analysis of Case-Control Studies

目的:运用Meta分析的方法评价缺氧诱导因子-1α(HIF-1α)与宫颈癌发病、病理类型、分化程度及侵袭性的关系。方法:计算机检索中国期刊全文数据库(1979—2010)、维普中文科技期刊数据库(1989—2010)、中国生物医学文献数据库(1979—2010)、万方数据库(1998—2010),同时手工检索所有纳入文献的参考文献,收集国内截止到2010年12月关于HIF-1α与宫颈癌发病、病理类型、分化程度及侵袭性关系的病例对照研究,按制定的纳入及排除标准筛选文献并评价文献质量。统计分析采用RevMan5.0软件进行。结果:共纳入13个病例对照研究,包括862例患者和243例对照。Meta分析结果显示:宫颈癌患者的HIF-1α阳性率明显高于对照组(OR=54.72,95%CI为28.87～103.70);HIF-1α在宫颈鳞癌组与非鳞癌组之间表达差异无统计学意义(OR=0.82,95%CI为0.39～1.75);HIF-1α在宫颈癌低分化组及高分化组之间表达差异有统计学意义(OR=5.00,95%CI为3.18～7.88);HIF-1α在宫颈癌淋巴结转移组的表达水平高于非转移组(OR=6.24,95%CI为2.90～13.44)。结论:HIF-1α在宫颈癌发病中可能起重要作用,其表达水平与宫颈癌分化程度及侵袭性有关。

Objective ：To explore the expression of HIF-1α in cervical cancer and evaluate their relationship. Methods： The published studies were searched in the CNKI （1979 to 2010）, VIP （1989 to 2010）,CBMdisc （1979 to 2010） and Wan_fang technological periodical full-text databases（ 1982 to 2010） and other relevant journals were also searched by hand, to identify all the relevant case -control trials, and the quality of the included studies were assessed. The data were analyzed by RevMan 5.0 software. Results：A total of 13 studies involving 862 patients and 243 controls were recruited. Meta-analysis results showed that the positive rate of HIF-lot expression in cervical cancer was significant higher than normal cervical tissues （0R=54.72,95%CI：28.87-103.70） ,and no significant differences was tested between cervical squamous cell carcinoma vs. non-squamous cell carcinoma （OR =0.82,95% CI：0.39- 1.75）,and significant differences was tested between lymphnode metastasis vs. no lymphnode metastasis, poorly differentiatedand vs. well differentiated with OR （95 % CI） at 6.24 （2.90-13.44 ）, 5.00 （3.18,7.88） respectively. Conclusions： The expression of HIF-1α is significantly associated with cervical cancer and its biological behavior.