阿拉伯、半乳和果呋喃寡糖的生物来源及合成进展

Review on Synthesis and Occurrence of Oligoarabino-, Oligogalacto- and Oligofructo-furanoses

由呋喃型阿拉伯糖、半乳糖和果糖构成的寡糖及其糖缀合物广泛分布于自然界,主要存在于植物和低等生物,如细菌、原生动物、真菌,是细胞壁糖肽、糖脂和核苷酸糖类的重要组成部分,具有广泛的生物学意义,其合成和化学生物学研究一直备受关注.综述了近年这些呋喃寡糖的生物来源及合成研究进展.

Oligofuranoses, such as oligoarabino-, oligogalato- and oligofructo-furanoses are widespread in plants and micro- organisms. They are important structural constituents of cell wall glycoconjugates of bacteria, fungi and plants, and they have also been identified in glycopeptides, glycolipids as well as nucleotides. Synthesis of these oligofuranosyl structural fragments is holding current appeal. This review will focus on the occurrence and the chemical and chemo-enzymatic syntheses of these natural oligofuranoses.