Linezolid——一种新噁唑烷酮类抗微生物药物

Linezolid——A New Kind of Antimicrobial Agents of Oxazolidinones

噁唑烷酮类药物是一类新的抗微生物制剂,在体外实验和动物感染模型实验中,此类药对革兰氏阳性菌(抗生素敏感的和耐药的)有很强抗菌活性。临床试验证实Linezolid口服给药的相对生物利用度为100％,噁唑烷酮类与其它抗生素无交叉耐药,且通过抑制细菌蛋白质合成的早期阶段而起作用。实验未筛选出耐药突变种。

The oxazolidinones are a new class of antimicrobial agents that possess promising activity against antibiotic -sensitive and - resistant gram - positive bacteria in vitro and in animal models of infection. In clinical trials, linezolid, demonstrated 100% bioaFailability after oral dosing. The oxazolidinones are not cross - resistant with other antimicrobial classes and act by inhibiting the formation of the initiation complex in bacterial protein synthesis. Laboratory testing to select for resistant mutants has met with only limited success.