体内外成像技术在给药系统肿瘤靶向性中的应用

In vitro and in vivo imaging applications in tumor targeting of drug delivery systems

给药系统肿瘤靶向性问题一直是研究的难点。体外凋亡、体内药代动力学等实验都不能直观观察给药系统在肿瘤治疗中的靶向性。而体内外成像技术则可以解决给药系统中肿瘤靶向性的问题，实验者不仅可以对给药系统在靶器官、靶组织、靶细胞中进行直观观察，还可对其进行定量、定性分析。

Drug delivery system in tumor targeting research has always been a difficult problem. Apopto- sis in vitro experiments and body pharmacokinetic experiments can not reflect the targeting of drug delivery system indirectly. Imaging techniques both in vivo and in vitro solve the problem, researchers can not only observe the drug delivery system in the target organ, the target tissue and target cell directly, but also ana- lyze quantitatively and qualitatively.