胰腺癌神经侵犯机制研究进展

Progress of neural invasion in pancreatic cancer

胰腺癌是一种起病隐匿、高度恶性的侵袭性肿瘤，嗜神经生长是胰腺癌的重要生物学特性之一，并且神经侵犯是影响胰腺癌预后的独立指标，但其机制尚未完全明晰。有关胰腺癌神经侵犯的机制研究，一直都是国内外学者探讨的热点，同时也是突破瓶颈的难点。有关胰腺癌机制的研究，从各种黏附分子到神经生长因子，从相关配体蛋白通路到易感基因的表达，大量文章都有报道，大大提高了临床医师对胰周神经侵犯的认识，同时在早期发现病变、延长患者生存期、提高生活质量等方面有着重要意义。本文对近年来胰腺癌神经侵犯相关研究成果及最新进展作一综述。

Pancreatic cancer is a kind of highly malignant aggressive cancers. Perinearal growth is one of the importcant biological characteristics of pancreatic cancer. Perineural invasion is an independent prognostic indicator of its prognosis. However, the mechanism has not yet completely clear. The pancreatic cancer perineural invasion mechanism research has been the focus of scholars to discuss, however it＇ s difficult to break through. Therefore, the discussion pancreatic violation of the peripancreatic neural mechanism for early clinical find, early treatment is essential. The mechanisms of pancreatic cancer research, from all kinds of adhesion molecule to the nerve growth factor, related ligand protein path to susceptibility gene expression, have been reported largely, which helps en- hance people＇ s awareness of peripancreatic neural invasion. At the same time, perineural invasion in the early de- tection of disease, prolonging survival period and improving the quality of life has important significance. Now the progresses of reviews in recent years are discussed as follows.