陆英抗肝炎活性成分的研究

Research on Sambucus Chinensis Lindl. Against hepatitis

从忍冬科接骨木属植物陆英中提取分离出 5种成分 ,经鉴定分别为乌索酸、齐墩果酸、α -香树脂醇、β -香树脂醇、β -谷甾醇。经动物实验和临床试验证实 :含量较高的乌索酸为陆英抗肝炎的主要活性成分 ,对CCL4引起的急性肝损伤大鼠血清SGPT及肝甘油三脂明显降低 ,血清甘油三脂及肝糖原含量增加 ,并能明显减轻肝细胞变性、坏死。临床应用乌索酸治疗病毒性肝炎 12 1例 ,治愈率 91 2 % ,明显优于同期对照组的疗效 (P <0 0 1)。

Five compositions are drown from the Sambucus Chinensis Lindl.of Caprifoliaecae Sambucus.After identification,they are repectively ursolic acid,oleanolic acid α-amyrin,β-amyrin and β-sitosterol.Tests on animal and clinical experiments show that the ursolic acid is the main active component of Sambucus Chinensis Lindl.Against hepatitis,and that it can apparently reduce Serum SGPT and Hepatic triglyceride of the rats,whose acute liver functions and damaged by the CCl 4.The tests also show the degeneration and necrosis of hepatic cells.121patients with virus hepatitis are treated by ursolic acid,and the cure rate is 91.2percent,which is superior to the control group(P<0.01). [